α1a Tubulin Antibody (7-RY28): sc-134237

α1a Tubulin Antibody (7-RY28) is a mouse monoclonal IgG2a kappa light chain antibody that detects α1a Tubulin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-α1a Tubulin antibody (7-RY28) is available as a non-conjugated format. Tubulin plays a crucial role in maintaining cell shape, enabling intracellular transport, and facilitating cell division, making it essential for proper cellular function and organization. The protein exists in five distinct forms, including α, β, γ, δ, and ε Tubulin, with α and β Tubulins forming heterodimers that polymerize to create microtubule filaments. These filaments are integral to the cytoskeleton, providing structural support and serving as tracks for motor proteins that transport cellular cargo. Notably, the dynamic nature of microtubules allows cells to adapt their shape and respond to various stimuli, which is vital for processes such as cell migration and division. α1a Tubulin protein is involved in the formation of stable microtubules that are critical for neuronal function and development. With exceptional specificity, α1a Tubulin monoclonal antibody (7-RY28) serves as an invaluable tool for researchers studying cytoskeletal dynamics and related cellular processes.

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α1a Tubulin Antibody (7-RY28) References:

1. Presence of the betaII isotype of tubulin in the nuclei of cultured mesangial cells from rat kidney.  |  Walss, C., et al. 1999. Cell Motil Cytoskeleton. 42: 274-84. PMID: 10223634
2. Identification of betaIII- and betaIV-tubulin isotypes in cold-adapted microtubules from Atlantic cod (Gadus morhua): antibody mapping and cDNA sequencing.  |  Modig, C., et al. 1999. Cell Motil Cytoskeleton. 42: 315-30. PMID: 10223637
3. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function.  |  Chang, P. and Stearns, T. 2000. Nat Cell Biol. 2: 30-5. PMID: 10620804
4. Tubulin immunoreactive neuronal intranuclear inclusions in the human brain.  |  Woulfe, J. and Munoz, D. 2000. Neuropathol Appl Neurobiol. 26: 161-71. PMID: 10840279
5. Alpha-, beta-, and gamma-tubulins: sequence comparisons and structural constraints.  |  Burns, RG. 1991. Cell Motil Cytoskeleton. 20: 181-9. PMID: 1773446
6. Refining the phenotype of alpha-1a Tubulin (TUBA1A) mutation in patients with classical lissencephaly.  |  Morris-Rosendahl, DJ., et al. 2008. Clin Genet. 74: 425-33. PMID: 18954413
7. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome.  |  Zheng, Y., et al. 1991. Cell. 65: 817-23. PMID: 1904010
8. Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration.  |  Belvindrah, R., et al. 2017. J Cell Biol. 216: 2443-2461. PMID: 28687665
9. The mutational and phenotypic spectrum of TUBA1A-associated tubulinopathy.  |  Hebebrand, M., et al. 2019. Orphanet J Rare Dis. 14: 38. PMID: 30744660
10. Invited review: the role of nucleotide triphosphate in actin and tubulin assembly and function.  |  Weisenberg, RC. 1981. Cell Motil. 1: 485-97. PMID: 6756643
11. Multiple forms of tubulin: different gene products and covalent modifications.  |  Ludueña, RF. 1998. Int Rev Cytol. 178: 207-75. PMID: 9348671
12. Expression of amino- and carboxyl-terminal gamma- and alpha-tubulin mutants in cultured epithelial cells.  |  Leask, A. and Stearns, T. 1998. J Biol Chem. 273: 2661-8. PMID: 9446570

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α1a Tubulin Antibody (7-RY28) has 20 citations in a variety of scientific publications.

Primary antibodies like Anti-α1a Tubulin Antibody (7-RY28) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α1a Tubulin Antibody (7-RY28) Specifications

Alternate Product Name: tubulin alpha 1a

Product Clone Name: 7-RY28

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 352-452

Epitope Target: α1a Tubulin

Epitope Species: human

Product Reactivity/Detection: α1a Tubulin and α Tubulin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 20 citations in various scientific publications

Available Conjugates/Forms for α1a Tubulin Antibody (7-RY28): N/A