α-Tocotrienol (CAS 58864-81-6)
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α-Tocotrienol functions as an antioxidant in experimental applications. It exerts its mechanism of action by scavenging free radicals and preventing oxidative damage to cells and biomolecules. α-Tocotrienol is known to inhibit lipid peroxidation and protect cell membranes from oxidative stress. At the molecular level, α-Tocotrienol interacts with reactive oxygen species, neutralizing their harmful effects and maintaining cellular homeostasis. Its ability to modulate redox signaling pathways contributes to its role in protecting cells from oxidative damage. α-Tocotrienol may regulate gene expression related to antioxidant defense, further enhancing its function in maintaining cellular health. α-Tocotrienol plays a role in experimental applications by serving as an effective antioxidant and protecting cells from oxidative stress.
α-Tocotrienol (CAS 58864-81-6) References
- Dietary alpha-tocopherol decreases alpha-tocotrienol but not gamma-tocotrienol concentration in rats. | Ikeda, S., et al. 2003. J Nutr. 133: 428-34. PMID: 12566479
- Intracellular mechanisms mediating tocotrienol-induced apoptosis in neoplastic mammary epithelial cells. | Sylvester, PW. and Shah, S. 2005. Asia Pac J Clin Nutr. 14: 366-73. PMID: 16326643
- Tocotrienol suppresses adipocyte differentiation and Akt phosphorylation in 3T3-L1 preadipocytes. | Uto-Kondo, H., et al. 2009. J Nutr. 139: 51-7. PMID: 19056650
- Tocotrienol vitamin E protects against preclinical canine ischemic stroke by inducing arteriogenesis. | Rink, C., et al. 2011. J Cereb Blood Flow Metab. 31: 2218-30. PMID: 21673716
- Increased α-tocotrienol content in seeds of transgenic rice overexpressing Arabidopsis γ-tocopherol methyltransferase. | Zhang, GY., et al. 2013. Transgenic Res. 22: 89-99. PMID: 22763462
- Tocotrienol prevents AAPH-induced neurite degeneration in neuro2a cells. | Fukui, K., et al. 2013. Redox Rep. 18: 238-44. PMID: 24112959
- Tocopherol and tocotrienol contents of different varieties of rice in Malaysia. | Shammugasamy, B., et al. 2015. J Sci Food Agric. 95: 672-8. PMID: 24841131
- Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's Disease. | Grimm, MO., et al. 2016. Int J Mol Sci. 17: PMID: 27801864
- Tocotrienols and tocopherols in colored-grain wheat, tritordeum and barley. | Lachman, J., et al. 2018. Food Chem. 240: 725-735. PMID: 28946335
- Cellular Uptake and Bioavailability of Tocotrienol-Rich Fraction in SIRT1-Inhibited Human Diploid Fibroblasts. | Jaafar, F., et al. 2018. Sci Rep. 8: 10471. PMID: 29992988
- Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage of Bcl-xL in Primary Hippocampal Neurons. | Park, HA., et al. 2019. Int J Mol Sci. 21: PMID: 31905614
- Oat (Avena sativa) Extract against Oxidative Stress-Induced Apoptosis in Human Keratinocytes. | Song, S., et al. 2021. Molecules. 26: PMID: 34577035
- Alpha-tocotrienol enhances arborization of primary hippocampal neurons via upregulation of Bcl-xL. | Park, HA., et al. 2022. Nutr Res. 101: 31-42. PMID: 35366596
- Suppression of Amyloid-β Adsorption on Endoplasmic Reticulum Stress-Mimicking Membranes by α-Tocopherol and α-Tocotrienol. | Nakatani, Y., et al. 2022. J Phys Chem Lett. 13: 11955-11960. PMID: 36534445
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Tocotrienol, 1 mg | sc-221191 | 1 mg | $64.00 | |||
α-Tocotrienol, 5 mg | sc-221191A | 5 mg | $260.00 | |||
α-Tocotrienol, 10 mg | sc-221191B | 10 mg | $460.00 | |||
α-Tocotrienol, 5.55 g | sc-221191C | 5.55 g | $16320.00 |