α-Spinasterol (CAS 481-18-5)
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α-Spinasterol is a phytosterol that may play a role in regulating the physical properties of the lipid bilayer, influencing the stability and functionality of cell membranes. At the molecular level, α-Spinasterol interacts with the hydrophobic core of the lipid bilayer, affecting its packing and organization. This modulation of membrane properties can impact the activity of membrane-bound proteins and enzymes, influencing various cellular processes. α-Spinasterol also has the potential to alter the responsiveness of cells to external stimuli by affecting the transmission of signals across the membrane. Its presence can contribute to the overall structural integrity and functionality of plant cell membranes, influencing their ability to maintain homeostasis and respond to environmental cues.
α-Spinasterol (CAS 481-18-5) References
- alpha-Spinasterol isolated from the root of Phytolacca americana and its pharmacological property on diabetic nephropathy. | Jeong, SI., et al. 2004. Planta Med. 70: 736-9. PMID: 15326549
- Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. | Trevisan, G., et al. 2012. J Pharmacol Exp Ther. 343: 258-69. PMID: 22837009
- Anti-inflammatory action of hydroalcoholic extract, dichloromethane fraction and steroid α-spinasterol from Polygala sabulosa in LPS-induced peritonitis in mice. | Borges, FR., et al. 2014. J Ethnopharmacol. 151: 144-50. PMID: 24161429
- α-Spinasterol from Melandrium firmum attenuates benign prostatic hyperplasia in a rat model. | Lee, MY., et al. 2014. Mol Med Rep. 9: 2362-6. PMID: 24682042
- α-Spinasterol, a TRPV1 receptor antagonist, elevates the seizure threshold in three acute seizure tests in mice. | Socała, K., et al. 2015. J Neural Transm (Vienna). 122: 1239-47. PMID: 25764210
- Evaluation of the antidepressant- and anxiolytic-like activity of α-spinasterol, a plant derivative with TRPV1 antagonistic effects, in mice. | Socała, K. and Wlaź, P. 2016. Behav Brain Res. 303: 19-25. PMID: 26808607
- A novel method for synthesis of α-spinasterol and its antibacterial activities in combination with ceftiofur. | Yang, X., et al. 2017. Fitoterapia. 119: 12-19. PMID: 28351722
- The Potential of α-Spinasterol to Mimic the Membrane Properties of Natural Cholesterol. | Haralampiev, I., et al. 2017. Molecules. 22: PMID: 28829376
- α-Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice. | Brusco, I., et al. 2017. Br J Pharmacol. 174: 4247-4262. PMID: 28849589
- The molecular basis of cytotoxicity of α-spinasterol from Ganoderma resinaceum: Induction of apoptosis and overexpression of p53 in breast and ovarian cancer cell lines. | Sedky, NK., et al. 2018. J Cell Biochem. 119: 3892-3902. PMID: 29143969
- Involvement of TRPV1 and the efficacy of α-spinasterol on experimental fibromyalgia symptoms in mice. | Fischer, SPM., et al. 2020. Neurochem Int. 134: 104673. PMID: 31926196
- Dual Beneficial Effects of α-Spinasterol Isolated from Aster pseudoglehnii on Glucose Uptake in Skeletal Muscle Cells and Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells. | Lee, D., et al. 2022. Plants (Basel). 11: PMID: 35270128
- Pharmacology of α-spinasterol, a phytosterol with nutraceutical values: A review. | Majeed, M., et al. 2022. Phytother Res. 36: 3681-3690. PMID: 35802356
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Spinasterol, 5 mg | sc-474404 | 5 mg | $439.00 |