Molecular structure of α-Melanocyte stimulating hormone, CAS Number: 581-05-5
α-Melanocyte stimulating hormone (CAS 581-05-5)
Alternate Names:
α-MSH; α-Melanotropin
Application:
α-Melanocyte stimulating hormone is an endogenous melanocortin receptor agonist
CAS Number:
581-05-5
Molecular Weight:
1664.88
Molecular Formula:
C77H109N21O19S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
α-Melanocyte stimulating hormone is an endogenous melanocortin receptor (MC-R) agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1-R, MC3-R, MC4-R and MC5-R receptors respectively). This peptide also shows anti-inflammatory properties and can antagonize many proinflammatory mediators, such as TNF-alpha, IL-^, and NO while also inducing cytokine IL-10 (anti-inflammatory). alpha-Melanocyte stimulating hormone is an inhibitor of NOS2.
α-Melanocyte stimulating hormone (CAS 581-05-5) References
- Influence of alpha-melanocyte-stimulating hormone and ultraviolet radiation on the transfer of melanosomes to keratinocytes. | Virador, VM., et al. 2002. FASEB J. 16: 105-7. PMID: 11729101
- alpha -melanocyte-stimulating hormone is a novel regulator of bone. | Cornish, J., et al. 2003. Am J Physiol Endocrinol Metab. 284: E1181-90. PMID: 12618359
- Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. | Lu, XY., et al. 2003. J Neurosci. 23: 7863-72. PMID: 12944516
- alpha-Melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage. | Böhm, M., et al. 2005. J Biol Chem. 280: 5795-802. PMID: 15569680
- Neuropeptide Y, alpha-melanocyte-stimulating hormone, and monoamines in food intake regulation. | Ramos, EJ., et al. 2005. Nutrition. 21: 269-79. PMID: 15723758
- Regulation of the mesocorticolimbic and mesostriatal dopamine systems by α-melanocyte stimulating hormone and agouti-related protein. | Roseberry, AG., et al. 2015. Neurosci Biobehav Rev. 56: 15-25. PMID: 26116876
- Characterization of receptors for alpha-melanocyte-stimulating hormone on human melanoma cells. | Siegrist, W., et al. 1989. Cancer Res. 49: 6352-8. PMID: 2804981
- Presence of immunoreactive alpha-melanotropin and beta-endorphin in spinal motoneurones of the dystrophic mouse. | Haynes, LW. and Smith, ME. 1985. Neurosci Lett. 58: 13-8. PMID: 2931622
- Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expression. | Kwon, BS., et al. 1988. Biochem Biophys Res Commun. 153: 1301-9. PMID: 3134020
- Antipyretic potency of centrally administered alpha-melanocyte stimulating hormone. | Murphy, MT., et al. 1983. Science. 221: 192-3. PMID: 6602381
- Localization of alpha-melanocyte-stimulating hormone in rat brain and pituitary. | Dubé, D., et al. 1978. Endocrinology. 102: 1283-91. PMID: 744026
- alpha-Melanocyte stimulating hormone in the modulation of host reactions. | Catania, A. and Lipton, JM. 1993. Endocr Rev. 14: 564-76. PMID: 8262006
- Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin. | Marcinkiewicz, M., et al. 1993. Proc Natl Acad Sci U S A. 90: 4922-6. PMID: 8389457
- The role of alpha-melanocyte-stimulating hormone in cutaneous biology. | Luger, TA., et al. 1997. J Investig Dermatol Symp Proc. 2: 87-93. PMID: 9487022
- Binding of alpha-melanocyte-stimulating hormone to its G-protein-coupled receptor on B-lymphocytes activates the Jak/STAT pathway. | Buggy, JJ. 1998. Biochem J. 331 (Pt 1): 211-6. PMID: 9512481
Inhibitor of:
NOS2.Activator of:
AIM1, CART, MATP, MC1-R, Melan-A, MFSD12, MITF, P protein, period, Pmel17, POMC, TGase3, TRP1, and TRP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Melanocyte stimulating hormone, 1 mg | sc-364762 | 1 mg | $84.00 | |||
α-Melanocyte stimulating hormone, 5 mg | sc-364762A | 5 mg | $210.00 | |||
α-Melanocyte stimulating hormone, 25 mg | sc-364762B | 25 mg | $926.00 |