Date published: 2025-12-15

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α-Hydroxyisobutyric acid (CAS 594-61-6)

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Alternate Names:
2-hydroxyisobutyric acid; 2-hydroxy-2-methylpropionic acid
Application:
α-Hydroxyisobutyric acid is a building block for polymer synthesis
CAS Number:
594-61-6
Molecular Weight:
104.10
Molecular Formula:
C4H8O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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α-Hydroxyisobutyric acid is a naturally occurring organic compound. Derived from isobutyric acid, it serves as a versatile compound with broad applications in scientific research. α-Hydroxyisobutyric acid finds extensive use in the scientific research field. One aspect of its metabolism involves the enzyme 3-hydroxyisobutyryl-CoA dehydrogenase, which plays a significant role in branched-chain amino acid metabolism. This enzyme facilitates the conversion of 3-hydroxyisobutyryl-CoA to acetoacetyl-CoA, impacting the metabolism of branched-chain amino acids, fatty acids, and glucose.


α-Hydroxyisobutyric acid (CAS 594-61-6) References

  1. An isobutyronitrile-induced bienzymatic system of Alcaligenes sp. MTCC 10674 and its application in the synthesis of α-hydroxyisobutyric acid.  |  Bhatia, SK., et al. 2013. Bioprocess Biosyst Eng. 36: 613-25. PMID: 22945851
  2. Elution profiles of lanthanides with α-hydroxyisobutyric acid by ion exchange chromatography using fine resin.  |  Trikha, R., et al. 2015. J Sep Sci. 38: 3810-4. PMID: 26333182
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  4. Carbohydrate Background Removal in Metabolomics Samples.  |  Yuan, J., et al. 2018. Anal Chem. 90: 14100-14104. PMID: 30474970
  5. Design and optimization of a fused-silica microfluidic device for separation of trivalent lanthanides by isotachophoresis.  |  Bottenus, D., et al. 2019. Electrophoresis. 40: 2531-2540. PMID: 31206758
  6. Dual Metabolomic Platforms Identified a Novel Urinary Metabolite Signature for Hepatitis B Virus-Infected Patients with Depression.  |  Xie, J., et al. 2020. Diabetes Metab Syndr Obes. 13: 1677-1683. PMID: 32547129
  7. Metabolite biomarkers of type 2 diabetes mellitus and pre-diabetes: a systematic review and meta-analysis.  |  Long, J., et al. 2020. BMC Endocr Disord. 20: 174. PMID: 33228610
  8. Recent Approaches for Chemical Speciation and Analysis by Electrospray Ionization (ESI) Mass Spectrometry.  |  Indelicato, S., et al. 2020. Front Chem. 8: 625945. PMID: 33553108
  9. Applications of Metabolomics in Forensic Toxicology and Forensic Medicine.  |  Szeremeta, M., et al. 2021. Int J Mol Sci. 22: PMID: 33809459
  10. Metabolome and transcriptome analysis of flavor components and flavonoid biosynthesis in fig female flower tissues (Ficus carica L.) after bagging.  |  Wang, Z., et al. 2021. BMC Plant Biol. 21: 396. PMID: 34433422
  11. Characterization of Leptoglossus occidentalis Eggs and Egg Glue.  |  Sánchez-Hernández, E., et al. 2023. Insects. 14: PMID: 37103211
  12. Metabolic biomarkers in lung cancer screening and early diagnosis (Review).  |  Xu, Y., et al. 2023. Oncol Lett. 25: 265. PMID: 37216157

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

α-Hydroxyisobutyric acid, 25 g

sc-257036
25 g
$28.00