Molecular structure of α-Fluoro-β-alanine, CAS Number: 3821-81-6
α-Fluoro-β-alanine (CAS 3821-81-6)
Alternate Names:
2-Fluoro-β-alanine; DL-2-Fluoro-3-alanine
Application:
α-Fluoro-β-alanine is an alanine derivative
CAS Number:
3821-81-6
Molecular Weight:
107.08
Molecular Formula:
C3H6FNO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
α-Fluoro-β-alanine represents a fluorinated variant of beta-alanine, an amino acid prevalent in various proteins. Operating as a competitive inhibitor, α-Fluoro-β-alanine has the capacity to modulate enzymes and proteins, thereby potentially inducing alterations in their structure and functionality. Moreover, α-Fluoro-β-alanine can engage with an array of molecules, including DNA, RNA, and lipids, and thereby exert an influence on gene expression. This multifaceted interaction highlights the potential impact of α-Fluoro-β-alanine on the intricate molecular landscape.
α-Fluoro-β-alanine (CAS 3821-81-6) References
- alpha-fluoro-beta-alanine: effects on the antitumor activity and toxicity of 5-fluorouracil. | Cao, S., et al. 2000. Biochem Pharmacol. 59: 953-60. PMID: 10692560
- Neurotoxic effects of alpha-fluoro-beta-alanine (FBAL) and fluoroacetic acid (FA) on dogs. | Yamashita, K., et al. 2004. J Toxicol Sci. 29: 155-66. PMID: 15206584
- Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes. | Fischel, JL., et al. 2004. Anticancer Drugs. 15: 969-74. PMID: 15514566
- Assay of urinary alpha-fluoro-beta-alanine by gas chromatography-mass spectrometry for the biological monitoring of occupational exposure to 5-fluorouracil in oncology nurses and pharmacy technicians. | Rubino, FM., et al. 2006. Biomed Chromatogr. 20: 257-66. PMID: 16167301
- Development of a sensitive and selective LC-MS/MS method for the determination of alpha-fluoro-beta-alanine, 5-fluorouracil and capecitabine in human plasma. | Licea-Perez, H., et al. 2009. J Chromatogr B Analyt Technol Biomed Life Sci. 877: 1040-6. PMID: 19285927
- Biological monitoring of occupational exposure to 5-fluorouracil: urinary α-fluoro-β-alanine assay by high performance liquid chromatography tandem mass spectrometry in health care personnel. | Ndaw, S., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 2630-4. PMID: 20207593
- Development, validation and application of a novel liquid chromatography tandem mass spectrometry assay measuring uracil, 5,6-dihydrouracil, 5-fluorouracil, 5,6-dihydro-5-fluorouracil, α-fluoro-β-ureidopropionic acid and α-fluoro-β-alanine in human plasma. | Chavani, O., et al. 2017. J Pharm Biomed Anal. 142: 125-135. PMID: 28501750
- Biomonitoring of occupational exposure to 5-FU by assaying α-fluoro-β-alanine in urine with a highly sensitive UHPLC-MS/MS method. | Dhersin, A., et al. 2018. Analyst. 143: 4110-4117. PMID: 30058665
- Enzymatic elimination of fluoride from alpha-fluoro-beta-alanine. | Porter, DJ., et al. 1995. Biochem Pharmacol. 50: 1475-84. PMID: 7503799
- Assessment of occupational exposure of pharmaceutical plant workers to 5-fluorouracil. Determination of alpha-fluoro-beta-alanine in urine. | Sessink, PJ., et al. 1994. J Occup Med. 36: 79-83. PMID: 8138854
- Selective 19F MR imaging of 5-fluorouracil and alpha-fluoro-beta-alanine. | Brix, G., et al. 1993. Magn Reson Imaging. 11: 1193-201. PMID: 8271906
- Simultaneous gas chromatographic-mass spectrophotometric determination of alpha-fluoro-beta-alanine and 5-fluorouracil in plasma. | Anderson, D., et al. 1997. J Chromatogr B Biomed Sci Appl. 688: 87-93. PMID: 9029317
- beta-alanine and alpha-fluoro-beta-alanine concentrative transport in rat hepatocytes is mediated by GABA transporter GAT-2. | Liu, M., et al. 1999. Am J Physiol. 276: G206-10. PMID: 9886997
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Fluoro-β-alanine, 25 mg | sc-220432 | 25 mg | $311.00 |