Molecular structure of α-Estradiol, CAS Number: 57-91-0
α-Estradiol (CAS 57-91-0)
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Alternate Names:
1,3,5(10)-Estratriene-3,17α-diol; 3,17α-Dihydroxy-1,3,5(10)-estratriene; Epiestradiol
Application:
α-Estradiol is a ligand for ERα and ERβ
CAS Number:
57-91-0
Purity:
≥96%
Molecular Weight:
272.38
Molecular Formula:
C18H24O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
α-Estradiol is a steroid hormone that is a major female sex hormone. It is produced in the ovaries and is involved in the regulation of the menstrual cycle, as well as the development of secondary sexual characteristics in females. α-Estradiol plays a role in the growth and maintenance of reproductive tissues, bone density, and the regulation of cholesterol levels. It has an impact on the brain, skin, and other organs. α-Estradiol functions by binding to estrogen receptors, which are present in various tissues. This binding activates specific genes and signaling pathways, leading to the diverse physiological effects of the hormone. α-Estradiol has important functions in males, including the regulation of sperm production and bone density. α-Estradiol is a key hormone with a wide range of biological effects.
α-Estradiol (CAS 57-91-0) References
- Calcium antagonistic effect of 17 alpha-estradiol derivatives: in vitro examinations. | Seeger, H., et al. 1999. Gynecol Endocrinol. 13: 246-8. PMID: 10533159
- The effects of beta-estradiol on SHSY5Y neuroblastoma cells during heavy metal induced oxidative stress, neurotoxicity and beta-amyloid secretion. | Olivieri, G., et al. 2002. Neuroscience. 113: 849-55. PMID: 12182891
- ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. | Toran-Allerand, CD., et al. 2002. J Neurosci. 22: 8391-401. PMID: 12351713
- Dehydroepiandrosterone and alpha-estradiol limit the functional alterations of rat brain mitochondria submitted to different experimental stresses. | Morin, C., et al. 2002. Neuroscience. 115: 415-24. PMID: 12421607
- beta-estradiol influences differentiation of hippocampal neurons in vitro through an estrogen receptor-mediated process. | Audesirk, T., et al. 2003. Neuroscience. 121: 927-34. PMID: 14580943
- Estradiol and raloxifene protect cultured SN4741 neurons against oxidative stress. | Biewenga, E., et al. 2005. Neurosci Lett. 373: 179-83. PMID: 15619539
- Estradiol administration mediates the inflammatory response to formalin in female rats. | Kuba, T., et al. 2005. Brain Res. 1047: 119-22. PMID: 15893295
- Estradiol and progesterone differentially regulate formalin-induced nociception in ovariectomized female rats. | Kuba, T., et al. 2006. Horm Behav. 49: 441-9. PMID: 16257405
- Removal of estrogenic pollutants from contaminated water using molecularly imprinted polymers. | Meng, Z., et al. 2005. Environ Sci Technol. 39: 8958-62. PMID: 16323800
- Changes in alpha-estradiol receptor and progesterone receptor expression in the locus coeruleus and preoptic area throughout the rat estrous cycle. | Helena, CV., et al. 2006. J Endocrinol. 188: 155-65. PMID: 16461543
- Effect of cooking on concentrations of β-estradiol and metabolites in model matrices and beef. | Braekevelt, E., et al. 2011. J Agric Food Chem. 59: 915-20. PMID: 21218831
- Targeted high-resolution ion mobility separation coupled to ultrahigh-resolution mass spectrometry of endocrine disruptors in complex mixtures. | Benigni, P., et al. 2015. Anal Chem. 87: 4321-5. PMID: 25818070
- Diverse effects of α-/β-estradiol on catalytic activities of human UDP-glucuronosyltransferases (UGT). | Zhu, L., et al. 2023. J Steroid Biochem Mol Biol. 225: 106196. PMID: 36181991
- Urinary estrogen excretion rates during pregnancy in the bovine. | Erb, RE., et al. 1968. J Dairy Sci. 51: 416-9. PMID: 5640402
- Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. | Kuiper, GG., et al. 1997. Endocrinology. 138: 863-70. PMID: 9048584
Inhibitor of:
5 alpha-Reductase 2, and SRD5A2L2.Activator of:
Estrogen Receptor, IQGAP1, and VCP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Estradiol, 50 mg | sc-204425 | 50 mg | $70.00 |