α-Dystrobrevin Antibody (B-1): sc-365102
- α-Dystrobrevin Antibody (B-1) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 351-371 within an internal region of α-Dystrobrevin of human origin
- recommended for detection of all isoforms of α-Dystrobrevin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for α-Dystrobrevin Antibody (B-1). This work is in progress.
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α-Dystrobrevin Antibody (B-1) is a mouse monoclonal IgM antibody that detects α-Dystrobrevin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). α-Dystrobrevin is a crucial component of the dystrophin glycoprotein complex, playing a significant role in maintaining the structural integrity of muscle cells and facilitating synapse maturation, which is vital for normal muscle function and neuromuscular transmission. α-Dystrobrevin is predominantly localized to the cytoplasmic side of the sarcolemma and is particularly concentrated at the neuromuscular junctions in skeletal muscle, where α-Dystrobrevin helps anchor the dystrophin complex to the cell membrane. α-Dystrobrevin is essential for the proper functioning of muscle fibers, and disruption can lead to severe muscle disorders, including Duchenne muscular dystrophy. Alternative splicing of α-Dystrobrevin results in several isoforms, such as γ-Dystrobrevin, δ-Dystrobrevin, ε-Dystrobrevin, and ζ-Dystrobrevin, which may have distinct roles in different tissues, further underscoring the complexity and importance in muscle and neuronal function. anti-α-Dystrobrevin antibody (B-1) is an invaluable tool for researchers studying the dystrophin complex and its implications in muscle pathology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Dystrobrevin Antibody (B-1) | sc-365102 | 200 µg/ml | $322.00 | |||
α-Dystrobrevin (B-1) Neutralizing Peptide | sc-365102 P | 100 µg/0.5 ml | $69.00 |