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α-D-Glucose Pentaacetate (CAS 604-68-2)

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Alternate Names:
1,2,3,4,6-Penta-O-acetyl-α-D-glucopyranose; Penta-O-acetyl-α-D-glucopyranoside
Application:
α-D-Glucose Pentaacetate is shown to cause an immediate increase in insulin output
CAS Number:
604-68-2
Molecular Weight:
390.34
Molecular Formula:
C16H22O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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α-D-Glucose Pentaacetate, a derivative of glucose, plays a pivotal role in carbohydrate chemistry research, particularly in the synthesis and modification of complex carbohydrates. This chemical compound is extensively utilized as a building block in the assembly of glycoconjugates and glycosylated molecules, serving as a precursor for the introduction of diverse functional groups and modifications onto the glucose scaffold. Researchers employ α-D-Glucose Pentaacetate in glycosylation reactions to introduce acetate groups at specific hydroxyl positions of glucose, enabling the precise manipulation of carbohydrate structures and properties. Moreover, this compound serves as a model substrate in enzymatic studies to investigate the substrate specificity and catalytic mechanisms of glycosyltransferase enzymes involved in glycan biosynthesis pathways. By elucidating the molecular interactions between α-D-Glucose Pentaacetate and glycosyltransferases, researchers aim to uncover the complex enzymatic processes governing glycan assembly and modification. Additionally, α-D-Glucose Pentaacetate finds applications in carbohydrate chemistry research for the synthesis of glycolipids, glycopeptides, and other glycoconjugates with tailored properties and functionalities. Through innovative synthetic strategies and advanced analytical techniques, researchers continue to harness the versatility of α-D-Glucose Pentaacetate to advance our understanding of carbohydrate biology and facilitate the development of novel biomaterials and diagnostics.


α-D-Glucose Pentaacetate (CAS 604-68-2) References

  1. Effects of extracellular pH upon the insulinotropic action of alpha-D-glucose pentaacetate.  |  Ayvaz, G., et al. 1999. Res Commun Mol Pathol Pharmacol. 103: 83-90. PMID: 10440573
  2. Effect of D-mannoheptulose upon the cationic and secretory responses to alpha-D-glucose pentaacetate in perifused rat pancreatic islets.  |  Jijakli, H. and Malaisse, WJ. 1999. Endocrine. 10: 219-24. PMID: 10484285
  3. Activation of glycogen synthase a in hepatocytes exposed to alpha-D-glucose pentaacetate.  |  Cancelas, J., et al. 2000. Int J Mol Med. 6: 197-9. PMID: 10891566
  4. Metabolism of alpha-D-[1,2-13C]glucose pentaacetate and alpha-D-glucose penta[2-13C]acetate in rat hepatocytes.  |  Malaisse, WJ., et al. 2000. Arch Biochem Biophys. 381: 61-6. PMID: 11019820
  5. Regulation of 86Rb+ outflow from pancreatic islets. I. Reciprocal changes in the response to glucose, tetraethylammonium and quinine.  |  Carpinelli, A. and Malaisse, WJ. 1980. Mol Cell Endocrinol. 17: 103-10. PMID: 6988247
  6. Stimulation of insulin release by alpha-D-glucose pentaacetate.  |  Malaisse, WJ., et al. 1997. Biochem Biophys Res Commun. 231: 435-6. PMID: 9070295
  7. Insulinotropic action of alpha-D-glucose pentaacetate: functional aspects.  |  Malaisse, WJ., et al. 1997. Am J Physiol. 273: E1090-101. PMID: 9435523
  8. Insulinotropic action of alpha-D-glucose pentaacetate: metabolic aspects.  |  Sener, A., et al. 1998. Mol Genet Metab. 64: 135-47. PMID: 9705238
  9. Inhibition of insulin release by alpha- and beta-D-galactose pentaacetate.  |  Malaisse, WJ. and Kadiata, MM. 1998. Int J Mol Med. 2: 331-2. PMID: 9855706
  10. Effects of alpha-D- and beta-L-glucose pentaacetate on effluent radioactivity from pancreatic islets labelled with [(32)P]phosphate and myo-[2-(3)H]inositol.  |  Louchami, K., et al. 1999. Int J Mol Med. 3: 181-4. PMID: 9917527

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

α-D-Glucose Pentaacetate, 25 g

sc-221182
25 g
$20.00