Molecular structure of α-CEHC
α-CEHC
Alternate Names:
3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-propanoic acid
Application:
α-CEHC is metabolite of α-tocopherol
Purity:
≥98%
Molecular Weight:
278.3
Molecular Formula:
C16H22O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
α-CEHC is The major urinary metabolite of alpha-tocopherol following vitamin E supplementation. The concentration in human serum ranges 5–10 pmol/ml yet increases significantly up to 200 pmol/ml upon supplementation with RRR-alpha-tocopherol. Only excreted when a threshold concentration of 7–9 µmol α-tocopherol/g total lipid in plasma was exceeded. Therefore, excretion of alpha-CEHC may be considered to be a marker of optimum vitamin E intake.
α-CEHC References
- Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of alpha- and gamma-tocopherol in human plasma. | Galli, F., et al. 2002. Free Radic Biol Med. 32: 333-40. PMID: 11841923
- Tocopherol metabolites 2, 5, 7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) and 2, 7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (gamma-CEHC) in human serum after a single dose of natural vitamin E. | Radosavac, D., et al. 2002. Eur J Nutr. 41: 119-24. PMID: 12111049
- Synthesis and analysis of conjugates of the major vitamin E metabolite, alpha-CEHC. | Pope, SA., et al. 2002. Free Radic Biol Med. 33: 807-17. PMID: 12208368
- In vitro antioxidant activity of 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC), a vitamin E metabolite. | Betancor-Fernandez, A., et al. 2002. Free Radic Res. 36: 915-21. PMID: 12420750
- Accumulation of vitamin E metabolites in the blood of renal failure patients. | Galli, F., et al. 2004. Clin Nutr. 23: 205-12. PMID: 15030960
- Anti-inflammatory effects of tocopherol metabolites. | Grammas, P., et al. 2004. Biochem Biophys Res Commun. 319: 1047-52. PMID: 15184087
- A comparison between the antioxidant and peroxynitrite-scavenging functions of the vitamin E metabolites alpha- and gamma-carboxyethyl-6-hydroxychromans. | Galli, F., et al. 2004. Int J Vitam Nutr Res. 74: 362-73. PMID: 15628675
- Quantitation of rat liver vitamin E metabolites by LC-MS during high-dose vitamin E administration. | Leonard, SW., et al. 2005. J Lipid Res. 46: 1068-75. PMID: 15722564
- The coantioxidative effects of carboxyethyl-6-hydroxychromans and alpha-Tocopherol. | Uto-Kondo, H., et al. 2007. J Nutr Sci Vitaminol (Tokyo). 53: 301-5. PMID: 17934234
- Isolation and identification of alpha-CEHC sulfate in rat urine and an improved method for the determination of conjugated alpha-CEHC. | Li, YJ., et al. 2008. J Agric Food Chem. 56: 11105-13. PMID: 18991451
- Association between 24 hour urinary α-tocopherol catabolite, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman (α-CEHC) and α-tocopherol intake in intervention and cross-sectional studies. | Imai, E., et al. 2011. Asia Pac J Clin Nutr. 20: 507-13. PMID: 22094834
- Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial. | Traber, MG., et al. 2017. Am J Clin Nutr. 105: 571-579. PMID: 28077381
- Testosterone represses urinary excretion of the alpha-tocopherol metabolite alpha-carboxymethylhydroxychroman in rats. | Fujita, N. and Takenaka, A. 2018. J Nutr Biochem. 62: 59-64. PMID: 30253278
- Associations of 24 h urinary excretions of α- and γ-carboxyethyl hydroxychroman with plasma α- and γ-tocopherol and dietary vitamin E intake in older adults: the Lifelines-MINUTHE Study. | Zhu, Y., et al. 2022. Eur J Nutr. 61: 3755-3765. PMID: 35718823
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-CEHC, 1 mg | sc-222430 | 1 mg | $44.00 | |||
α-CEHC, 5 mg | sc-222430A | 5 mg | $146.00 |