Molecular structure of α-Bungarotoxin, CAS Number: 11032-79-4
α-Bungarotoxin (CAS 11032-79-4)
See product citations (5)
Application:
α-Bungarotoxin is an α-neurotoxin which competitively and irreversibly binds and blocks nAChR
CAS Number:
11032-79-4
Molecular Weight:
7984.3
Molecular Formula:
C338H529N97O105S11
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
α-Bungarotoxin binds nicotinic acetylcholine receptors and has been used to isolate and study them. It blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor but does not depress acetylcholine release from motor nerve endings. α-Bungarotoxin (alpha-BuTx) may act to bind mainly to sequences around the two cysteines at positions 192 and 193 of the AChR alpha-subunit of most species. It blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells, and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-Bungarotoxin on neuronal AChR to be highly specific for the alpha7-subtype, but not for the alpha3beta4 subtype. α-Bungarotoxin is an inhibitor of AChR alpha7.
α-Bungarotoxin (CAS 11032-79-4) References
- Chemical modification of arginine residues in alpha-bungarotoxin. | Lin, SR. and Chang, CC. 1992. Biochim Biophys Acta. 1159: 255-61. PMID: 1390930
- Localization of 3H-nicotine, 125I-kappa-bungarotoxin, and 125I-alpha-bungarotoxin binding to nicotinic sites in the chicken forebrain and midbrain. | Sorenson, EM. and Chiappinelli, VA. 1992. J Comp Neurol. 323: 1-12. PMID: 1430311
- In vitro quantitative autoradiography of [125I]alpha-bungarotoxin binding at the motor end-plates of experimental autoimmune myasthenia gravis. | Motomura, M., et al. 1992. Neurosci Lett. 143: 139-42. PMID: 1436658
- Acetylcholine receptor-alpha-bungarotoxin interactions: determination of the region-to-region contacts by peptide-peptide interactions and molecular modeling of the receptor cavity. | Ruan, KH., et al. 1990. Proc Natl Acad Sci U S A. 87: 6156-60. PMID: 2385590
- Expression and refolding of bioactive α-bungarotoxin V31 in E. coli. | Xu, J., et al. 2015. Protein Expr Purif. 110: 30-6. PMID: 25562180
- Improved Long-Term Imaging of Embryos with Genetically Encoded α-Bungarotoxin. | Swinburne, IA., et al. 2015. PLoS One. 10: e0134005. PMID: 26244658
- DNA Aptamers against Taiwan Banded Krait α-Bungarotoxin Recognize Taiwan Cobra Cardiotoxins. | Chen, YJ., et al. 2016. Toxins (Basel). 8: PMID: 26959062
- In vivo injection of α-bungarotoxin to improve the efficiency of motor endplate labeling. | Chen, W., et al. 2016. Brain Behav. 6: e00468. PMID: 27186443
- Structural basis for α-bungarotoxin insensitivity of neuronal nicotinic acetylcholine receptors. | Sine, SM., et al. 2019. Neuropharmacology. 160: 107660. PMID: 31163179
- Golden Anniversary of the Nicotinic Receptor. | Changeux, JP. 2020. Neuron. 107: 14-16. PMID: 32645305
- Chemical Synthesis of a Functional Fluorescent-Tagged α-Bungarotoxin. | Brun, O., et al. 2022. Toxins (Basel). 14: PMID: 35202107
- alpha-Bungarotoxin binds to low-affinity nicotine binding sites in rat brain. | Wonnacott, S. 1986. J Neurochem. 47: 1706-12. PMID: 3772372
- Neuronal acetylcholine receptors that bind alpha-bungarotoxin with high affinity function as ligand-gated ion channels. | Zhang, ZW., et al. 1994. Neuron. 12: 167-77. PMID: 7507338
- Alpha-Bungarotoxin binding to human muscle acetylcholine receptor: measurement of affinity, delineation of AChR subunit residues crucial to binding, and protection of AChR function by synthetic peptides. | Vincent, A., et al. 1998. Neurochem Int. 32: 427-33. PMID: 9676741
- Unmasking the functions of the chromaffin cell alpha7 nicotinic receptor by using short pulses of acetylcholine and selective blockers. | López, MG., et al. 1998. Proc Natl Acad Sci U S A. 95: 14184-9. PMID: 9826675
Inhibitor of:
α9-nAChR, AChRα1, AChRα10, AChRα4, AChRα5, AChRα9, AChRβ3, AChRδ, AChRγ, CHRFAM7A, CHRNB4, EG666827, Ly-6F, Mas 7, Olfr449, Olfr45, Olfr450, Olfr452, Olfr453, Olfr851, Olfr853, Olfr854, Olfr987, Olfr988, OR5K4, Rapsyn, RIC-3, SLURP1, Vmn2r106, Vmn2r110, Vmn2r31, and Vmn2r33.Activator of:
C6orf134.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Bungarotoxin, 1 mg | sc-202897 | 1 mg | $344.00 | |||
| US: Only available in the US | ||||||