Molecular structure of α,β-Thujone, CAS Number: 76231-76-0
α,β-Thujone (CAS 76231-76-0)
Alternate Names:
(−)-1-Isopropyl-4-methylbicyclo[3.1.0]hexan-3-one
CAS Number:
76231-76-0
Molecular Weight:
152.23
Molecular Formula:
C10H16O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
α,β-Thujone functions as a GABA receptor antagonist, inhibiting the activity of GABA receptors in the central nervous system. α,β-Thujone is known to disrupt the normal inhibitory signaling of GABA, leading to an excitatory effect on neurons. By interfering with the GABAergic neurotransmission, α,β-Thujone can modulate neuronal activity and affect synaptic transmission. In experimental applications, α,β-Thujone is utilized to investigate the role of GABA receptors in neuronal signaling and to study the effects of GABAergic modulation on synaptic transmission. Its ability to interact with GABA receptors may be useful in understanding the molecular mechanisms underlying neuronal communication and synaptic plasticity.
α,β-Thujone (CAS 76231-76-0) References
- Essential oils from dalmatian sage (Salvia officinalis l.): variations among individuals, plant parts, seasons, and sites. | Perry, NB., et al. 1999. J Agric Food Chem. 47: 2048-54. PMID: 10552494
- Determination of the biologically active flavour substances thujone and camphor in foods and medicines containing sage (Salvia officinalis L.). | Walch, SG., et al. 2011. Chem Cent J. 5: 44. PMID: 21777420
- Augmentation of humoral and cell mediated immune responses by Thujone. | Siveen, KS. and Kuttan, G. 2011. Int Immunopharmacol. 11: 1967-75. PMID: 21884824
- The choice of thujone as drug for diabetes. | Lachenmeier, DW. and Walch, SG. 2011. Nat Prod Res. 25: 1890-2. PMID: 21988529
- Seasonal influence on gene expression of monoterpene synthases in Salvia officinalis (Lamiaceae). | Grausgruber-Gröger, S., et al. 2012. J Plant Physiol. 169: 353-9. PMID: 22196947
- Essential oils and their compositions as spatial repellents for pestiferous social wasps. | Zhang, QH., et al. 2013. Pest Manag Sci. 69: 542-52. PMID: 23081867
- Identification of 1,8-cineole, borneol, camphor, and thujone as anti-inflammatory compounds in a Salvia officinalis L. infusion using human gingival fibroblasts. | Ehrnhöfer-Ressler, MM., et al. 2013. J Agric Food Chem. 61: 3451-9. PMID: 23488631
- Pro-apoptotic and anti-angiogenic properties of the α /β-thujone fraction from Thuja occidentalis on glioblastoma cells. | Torres, A., et al. 2016. J Neurooncol. 128: 9-19. PMID: 26900077
- A new chemical tool for absinthe producers, quantification of α/β-thujone and the bitter components in Artemisia absinthium. | Bach, B., et al. 2016. Food Chem. 213: 813-817. PMID: 27451252
- Therapeutic potential of α,β-thujone through metabolic reprogramming and caspase-dependent apoptosis in ovarian cancer cells. | Lee, JY., et al. 2021. J Cell Physiol. 236: 1545-1558. PMID: 33000501
- The effects of water deficit on the expression of monoterpene synthases and essential oils composition in Salvia ecotypes. | Ramezani, S., et al. 2020. Physiol Mol Biol Plants. 26: 2199-2207. PMID: 33268923
- Quantitative analysis of alpha, beta-thujone, pulegone, safrole, coumarin and beta-asarone in alcoholic beverages by selected-ion monitoring. | Galli, CL., et al. 1984. J Appl Toxicol. 4: 273-6. PMID: 6512167
- Aromatic compounds in some species of leucas r. br.(labiatae): with 2 tables (Labiatae) | Singh, T. P., & Kamat, M. 2001. Feddes Repertorium. 112(5‐6): 343-348.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α,β-Thujone, 10 ml | sc-239168 | 10 ml | $119.00 |