Molecular structure of α-Amyloid Precursor Protein Modulator, CAS Number: 497259-23-1
α-Amyloid Precursor Protein Modulator (CAS 497259-23-1)
See product citations (2)
Alternate Names:
α-Amyloid Precursor Protein Modulator is also known as PKC Activator V.
Application:
α-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam derived PKC activator displaying a marked loss of tumor promoting activity.
CAS Number:
497259-23-1
Purity:
≥95%
Molecular Weight:
501.55
Molecular Formula:
C27H30F3N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
alpha-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCalpha). α-Amyloid Precursor Protein Modulator efficiently enhances non-amyloidogenic alpha-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. alpha-Amyloid Precursor Protein Modulator displays a marked loss of tumor promoting activity.
α-Amyloid Precursor Protein Modulator (CAS 497259-23-1) References
- New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha. | Kozikowski, AP., et al. 2003. J Med Chem. 46: 364-73. PMID: 12540236
Inhibitor of:
DGK-α, and TGaseZ.Activator of:
Enzyme, OTTMUSG00000016698, OTTMUSG00000016703, and PKC.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Amyloid Precursor Protein Modulator, 1 mg | sc-204424 | 1 mg | $322.00 |