α-2 antiplasmin Antibody (MAP25C3): sc-59642

α-2 antiplasmin Antibody (MAP25C3) is a mouse monoclonal IgG1 kappa light chain antibody that detects α-2 antiplasmin of mouse origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). α-2 antiplasmin (MAP25C3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. As a member of the serine proteinase inhibitors (serpins) superfamily, α-2 antiplasmin plays a crucial role in regulating fibrinolysis, which is the process of breaking down blood clots. α-2 antiplasmin is secreted as a glycoprotein and contains a unique peptide stretch that mimics the substrate for serine proteases, allowing effective inhibition of plasmin, the enzyme responsible for clot degradation. α-2 antiplasmin maintains hemostatic balance; impaired function can lead to excessive bleeding due to unregulated plasmin activity. By competing with plasminogen for binding sites on fibrin, α-2 antiplasmin ensures that clot formation and dissolution are tightly controlled, highlighting an essential role in both coagulation and wound healing processes.

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α-2 antiplasmin Antibody (MAP25C3) References:

1. Alpha(2)-antiplasmin gene deficiency in mice does not affect neointima formation after vascular injury.  |  Lijnen, HR., et al. 2000. Arterioscler Thromb Vasc Biol. 20: 1488-92. PMID: 10845862
2. Inactivation of the serpin alpha(2)-antiplasmin by stromelysin-1.  |  Lijnen, HR., et al. 2001. Biochim Biophys Acta. 1547: 206-13. PMID: 11410276
3. Crosslinking of alpha 2-antiplasmin to fibrin.  |  Lee, KN., et al. 2001. Ann N Y Acad Sci. 936: 335-9. PMID: 11460490
4. Differences between neonates and adults in carbohydrate sequences and reaction kinetics of plasmin and alpha(2)-antiplasmin.  |  Ries, M., et al. 2002. Thromb Res. 105: 247-56. PMID: 11927131
5. Lack of alpha 2-antiplasmin promotes re-endothelialization via over-release of VEGF after vascular injury in mice.  |  Matsuno, H., et al. 2003. Blood. 102: 3621-8. PMID: 12893771
6. [Inhibition of the process of Glu-plasminogen activation by tissue activator with fibrin, DDE-complex, and D-dimer using alpha-2-antiplasmin].  |  Hrynenko, TV., et al. 2005. Ukr Biokhim Zh (1999). 77: 45-51. PMID: 16846069
7. Visceral obesity and hemostatic profile in patients with type 2 diabetes: the effect of gender and metabolic compensation.  |  Kozek, E., et al. 2004. Rev Diabet Stud. 1: 122-8. PMID: 17491674
8. Decreased levels of PAI-1 and alpha 2-antiplasmin contribute to enhanced fibrinolytic activity in divers.  |  Radziwon, P., et al. 2007. Thromb Res. 121: 235-40. PMID: 17521709

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α-2 antiplasmin Antibody (MAP25C3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-α-2 antiplasmin Antibody (MAP25C3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α-2 antiplasmin Antibody (MAP25C3) Specifications

Alternate Product Name: α-2 antiplasmin

Product Clone Name: MAP25C3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: α-2 antiplasmin

Epitope Species: mouse

Product Reactivity/Detection: α-2 antiplasmin

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for α-2 antiplasmin Antibody (MAP25C3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin