α-1-Microglobulin Antibody (10A12): sc-135665

α-1-Microglobulin Antibody (10A12) is a mouse monoclonal IgG1 antibody that detects α-1-Microglobulin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). α-1-Microglobulin (10A12) antibody is available as the non-conjugated form. α-1-Microglobulin, also known as protein HC, is a 184 amino acid secreted peptide that plays a crucial role in various physiological processes, including the transport of small hydrophobic molecules and the modulation of inflammatory responses. α-1-Microglobulin is primarily located in bodily fluids such as urine, plasma, and cerebrospinal fluid, where α-1-Microglobulin acts as a carrier for various ligands, thereby influencing their bioavailability and activity. α-1-Microglobulin interacts with fibronectin, a key extracellular matrix protein, suggesting involvement in tissue repair and cellular signaling pathways. The gene encoding α-1-Microglobulin precursor, AMBP, is located on human chromosome 9, a region associated with several genetic disorders, including hereditary hemorrhagic telangiectasia and familial dysautonomia. The presence of α-1-Microglobulin in these fluids and interactions highlight potential as a biomarker for various diseases, making α-1-Microglobulin (10A12) monoclonal antibody an essential tool for researchers studying physiological and pathological roles.

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α-1-Microglobulin Antibody (10A12) References:

1. Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties.  |  Allhorn, M., et al. 2002. Blood. 99: 1894-901. PMID: 11877257
2. Human alpha-1-microglobulin is covalently bound to kynurenine-derived chromophores.  |  Sala, A., et al. 2004. J Biol Chem. 279: 51033-41. PMID: 15452109
3. Structure of the human alpha 1-microglobulin-bikunin gene.  |  Vetr, H. and Gebhard, W. 1990. Biol Chem Hoppe Seyler. 371: 1185-96. PMID: 1708673
4. Up-regulation of alpha1-microglobulin by hemoglobin and reactive oxygen species in hepatoma and blood cell lines.  |  Olsson, MG., et al. 2007. Free Radic Biol Med. 42: 842-51. PMID: 17320766
5. SAXS studies of human protein HC (alpha1-microglobulin).  |  Kozak, M. and Grubb, A. 2007. Protein Pept Lett. 14: 425-9. PMID: 17584166
6. The lipocalin alpha1-microglobulin has radical scavenging activity.  |  Akerström, B., et al. 2007. J Biol Chem. 282: 31493-503. PMID: 17766242
7. Sequence of a full length cDNA coding for human protein HC (alpha 1 microglobulin).  |  Traboni, C. and Cortese, R. 1986. Nucleic Acids Res. 14: 6340. PMID: 2428011