Date published: 2026-6-8

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Alosetron Hydrochloride (CAS 122852-69-1)

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Application:
Alosetron Hydrochloride is a serotonin SR-3 (5HT3-receptor) antagonist
CAS Number:
122852-69-1
Molecular Weight:
330.81
Molecular Formula:
C17H19ClN4O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Alosetron Hydrochloride is a compound that is primarily investigated for its role in modulating serotonergic signaling. In research focused on the enteric nervous system, Alosetron Hydrochloride is employed to study its affinity and selectivity for the 5-HT3 receptor, a type of serotonin receptor found predominantly in the gastrointestinal tract. This compound helps scientists understand the complex pathways involved in gut motility and visceral sensitivity. Research on Alosetron Hydrochloride contributes to the broader field of neurogastroenterology, particularly in dissecting the neurochemical control of gastrointestinal functions. Additionally, its effects on ionic channels through 5-HT3 receptor interaction are of interest in electrophysiological studies. The compound is also used as a tool in the investigation of the mechanisms underlying the modulation of the enteric nervous system and its communication with the central nervous system.


Alosetron Hydrochloride (CAS 122852-69-1) References

  1. Consultant suspended for research fraud.  |  Ferriman, A. 2000. BMJ. 321: 1429. PMID: 11110724
  2. Novel medications for the irritable bowel syndrome: motility and sensation.  |  Camilleri, M. 2001. J Pediatr Gastroenterol Nutr. 32 Suppl 1: S35-7. PMID: 11321419
  3. Lower gastrointestinal disease in women.  |  Smith, RP. 2001. Obstet Gynecol Clin North Am. 28: 351-61, viii. PMID: 11430181
  4. FDA advisory panels recommend Lotronex be put back on market.  |  Charatan, F. 2002. BMJ. 324: 1053. PMID: 11993482
  5. FDA allows controversial bowel drug back on to market.  |  McCarthy, M. 2002. Lancet. 359: 2095. PMID: 12086774
  6. Incidence of colonic ischemia, hospitalized complications of constipation, and bowel surgery in relation to use of alosetron hydrochloride.  |  Miller, DP., et al. 2003. Am J Gastroenterol. 98: 1117-22. PMID: 12809837
  7. Integrating pharmacogenetics into society: in search of a model.  |  Webster, A., et al. 2004. Nat Rev Genet. 5: 663-9. PMID: 15372088
  8. Safety advisory group gets mixed marks from members.  |  Thompson, CA. 2005. Am J Health Syst Pharm. 62: 236, 238-9. PMID: 15719575
  9. Pharmacogenetics and geographical ancestry: implications for drug development and global health.  |  Daar, AS. and Singer, PA. 2005. Nat Rev Genet. 6: 241-6. PMID: 15738965
  10. Acute hepatitis associated with alosetron (Lotronex).  |  Turgeon, DK., et al. 2005. J Clin Gastroenterol. 39: 641-2. PMID: 16000936
  11. Novelty stress increases fecal pellet output in mongolian gerbils: effects of several drugs.  |  Okano, S., et al. 2005. J Pharmacol Sci. 98: 411-8. PMID: 16079466
  12. Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective.  |  Lewis, JH. 2010. Expert Rev Gastroenterol Hepatol. 4: 13-29. PMID: 20136586
  13. Optimizing outcomes with alosetron hydrochloride in severe diarrhea-predominant irritable bowel syndrome.  |  Lucak, SL. 2010. Therap Adv Gastroenterol. 3: 165-72. PMID: 21180598
  14. Retrospective clinical analysis for drug rescue: for new indications or stratified patient groups.  |  Cavalla, D. and Singal, C. 2012. Drug Discov Today. 17: 104-9. PMID: 22001144
  15. [Establishment of a canine slow transit constipation model and evalution of defecation, gastrointestinal transit and pathological sections].  |  Zhu, D., et al. 2018. Zhonghua Yi Xue Za Zhi. 98: 1786-1791. PMID: 29925160

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Alosetron Hydrochloride, 10 mg

sc-210788
10 mg
$205.00