Aloperine (CAS 56293-29-9)
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Aloperine is an alkaloid found in the roots of S. flavescens with diverse biological activities including antiviral, anticancer, antioxidant, and anti-inflammatory actions. It inhibits HIV-1 replication and envelope-mediated cell-cell fusion (EC50s = 1.75 and 1.2 μM, respectively) at concentrations well below the cytotoxic concentration (CC50) of >86.5 μM in vitro. Aloperine inhibits the growth of HL-60, U937, and K562 leukemia cell lines with IC50 values of 40, 270, and 360 μM, respectively. Administration of aloperine, at a dose of 60 mg/kg, reduces NOX2, NOX4, superoxide dismutase, and glutathione peroxidase expression in lungs in a rat model of pulmonary hypertension. Topical administration of aloperine reduces ear swelling, ear erythema, and production of inflammatory cytokines TNF-α, IL-1β, and IL-6 in a mouse model of allergic contact dermatitis.
Aloperine (CAS 56293-29-9) References
- Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3K/Akt signaling pathway. | Liu, JS., et al. 2019. Phytomedicine. 61: 152843. PMID: 31039533
- Aloperine suppresses LPS-induced macrophage activation through inhibiting the TLR4/NF-κB pathway. | Ye, Y., et al. 2020. Inflamm Res. 69: 375-383. PMID: 32144444
- Cytochrome P450s regulates aloperine-induced pathological changes in mouse liver and kidney. | Qiu, M., et al. 2020. Res Vet Sci. 132: 97-100. PMID: 32544634
- Aloperine inhibits hepatitis C virus entry into cells by disturbing internalisation from endocytosis to the membrane fusion process. | Lv, XQ., et al. 2020. Eur J Pharmacol. 883: 173323. PMID: 32622669
- Aloperine can reverse the cisplatin resistance of colorectal cancer cells via suppressing the HIF-1α/ERK signaling pathway. | Zheng, H., et al. 2020. Pharmazie. 75: 581-585. PMID: 33239133
- Aloperine protects human retinal pigment epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis through activation of Nrf2/HO-1 pathway. | Zhang, J., et al. 2022. J Recept Signal Transduct Res. 42: 88-94. PMID: 33256538
- A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms. | Zhou, H., et al. 2020. Front Pharmacol. 11: 538137. PMID: 33536900
- Aloperine Inhibits Proliferation and Promotes Apoptosis in Colorectal Cancer Cells by Regulating the circNSUN2/miR-296-5p/STAT3 Pathway. | Han, W., et al. 2021. Drug Des Devel Ther. 15: 857-870. PMID: 33664565
- Aloperine improves osteoporosis in ovariectomized mice by inhibiting RANKL-induced NF-κB, ERK and JNK approaches. | Hu, R., et al. 2021. Int Immunopharmacol. 97: 107720. PMID: 33945918
- Research Progress on the Natural Product Aloperine and Its Derivatives. | Cheng, Y., et al. 2022. Mini Rev Med Chem. 22: 729-742. PMID: 34488611
- Beneficial effects of aloperine on inflammation and oxidative stress by suppressing necroptosis in lipopolysaccharide-induced acute lung injury mouse model. | Cui, YR., et al. 2022. Phytomedicine. 100: 154074. PMID: 35397283
- Aloperine: A Potent Modulator of Crucial Biological Mechanisms in Multiple Diseases. | Tahir, M., et al. 2022. Biomedicines. 10: PMID: 35453655
- The plant-derived alkaloid aloperine prevents ischemia/reperfusion injury-induced sudden cardiac death. | Hu, Z., et al. 2023. FASEB J. 37: e22999. PMID: 37249366
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aloperine, 100 mg | sc-233847 | 100 mg | $150.00 |