Molecular structure of Aloisine, RP106, CAS Number: 496864-15-4
Aloisine, RP106 (CAS 496864-15-4)
Application:
Aloisine, RP106 is a selective, potent, ATP-competitive inhibitor of Cdc 2 (CDK1)/cyclin B, CDK5/p25, and GSK-3
CAS Number:
496864-15-4
Purity:
≥95%
Molecular Weight:
281.4
Molecular Formula:
C17H19N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Aloisine, RP106 is a cell-permeable pyrrolo-pyrazine compound known to exert anti-proliferative effects. It has been shown to act as a selective, potent, ATP-competitive inhibitor of Cdc 2 (CDK1)/cyclin B, CDK5/p25, and GSK-3.
Aloisine, RP106 (CAS 496864-15-4) References
- Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. | Mettey, Y., et al. 2003. J Med Chem. 46: 222-36. PMID: 12519061
- 3D QSAR studies on GSK-3 inhibition by aloisines. | Zeng, M., et al. 2005. Bioorg Med Chem Lett. 15: 395-9. PMID: 15603961
- Mechanism of CDK5/p25 binding by CDK inhibitors. | Mapelli, M., et al. 2005. J Med Chem. 48: 671-9. PMID: 15689152
- Chk2-mediated G2/M cell cycle arrest maintains radiation resistance in malignant meningioma cells. | Gogineni, VR., et al. 2011. Cancer Lett. 313: 64-75. PMID: 21945852
- Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates. | Löffler, T., et al. 2012. J Mol Neurosci. 47: 192-203. PMID: 22351109
- Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors. | Li, PH., et al. 2016. J Med Chem. 59: 238-52. PMID: 26649766
- Structural Bioinformatics Approach of Cyclin-Dependent Kinases 1 and 3 Complexed with Inhibitors. | Saraiva, LA., et al. 2011. Mol Inform. 30: 219-31. PMID: 27466775
- PIM 3 kinase, a proto-oncogene product, regulates phosphorylation of the measles virus nucleoprotein tail domain at Ser 479 and Ser 510. | Sugai, A., et al. 2020. Biochem Biophys Res Commun. 531: 267-274. PMID: 32800554
- Activation of platelet-derived growth factor receptor β in the severe fever with thrombocytopenia syndrome virus infection. | Tani, H., et al. 2020. Antiviral Res. 182: 104926. PMID: 32882323
- Synthesis, Characterisation and Docking Studies of Thioxoquinoline Derivatives as Potential Anti-Alzheimer Agents. | Naik, SP., et al. 2022. Curr Drug Discov Technol. 19: e130522204744. PMID: 35570516
Inhibitor of:
Cdc2, Cdk5, cyclin B, GSK, and p35.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aloisine, RP106, 1 mg | sc-202452 | 1 mg | $31.00 | |||
Aloisine, RP106, 5 mg | sc-202452A | 5 mg | $139.00 |