Alloxan monohydrate (CAS 2244-11-3)
QUICK LINKS
Alloxan monohydrate is a chemical compound utilized in research applications primarily for its ability to induce diabetes in experimental models. It is used to understand the pathophysiology of diabetes mellitus and to study the function of pancreatic β-cells. The mechanism involves selective toxicity towards these cells, leading to a decrease in insulin production, which mimics the condition of Type 1 diabetes. Alloxan monohydrate achieves this through the generation of reactive oxygen species (ROS), which cause oxidative stress and cellular damage. In addition to its use in diabetes research, the compound is also employed in studies investigating the protective effects of various antioxidants. Its role in the induction of a diabetic state makes it useful in the screening of compounds that could potentially modulate oxidative stress and metabolic dysfunction. Moreover, the structural similarity of alloxan monohydrate to uric acid allows for its use in studies pertaining to purine metabolism.
Alloxan monohydrate (CAS 2244-11-3) References
- Hypoglycemic effects of vanadium on alloxan monohydrate induced diabetic dogs. | Kim, JM., et al. 2006. J Vet Sci. 7: 391-5. PMID: 17106233
- Neurochemical correlates of alloxan diabetes: glucose and related brain metabolism in the rat. | Ahmed, N. and Zahra, N. 2011. Neurochem Res. 36: 494-505. PMID: 21188517
- Renal damage following Alloxan-induced diabetes is associated with generation of reactive oxygen species, alterations of p53, TGF-β1, and extracellular matrix metalloproteinases in rats. | Abdel Aziz, MA., et al. 2017. Cell Biol Int. 41: 525-533. PMID: 28220578
- In Vivo Hypoglycemic Effect of Kigelia africana (Lam): Studies With Alloxan-Induced Diabetic Mice. | Njogu, SM., et al. 2018. J Evid Based Integr Med. 23: 2515690X18768727. PMID: 29651878
- β-cell Regenerative Potential of Selected Herbal Extracts in Alloxan Induced Diabetic Rats. | Attanayake, AP., et al. 2019. Curr Drug Discov Technol. 16: 278-284. PMID: 29669500
- Antidiabetic potential of Caralluma europaea against alloxan-induced diabetes in mice. | Dra, LA., et al. 2019. Saudi J Biol Sci. 26: 1171-1178. PMID: 31516346
- Rutin ameliorates metabolic acidosis and fibrosis in alloxan induced diabetic nephropathy and cardiomyopathy in experimental rats. | Ganesan, D., et al. 2020. Mol Cell Biochem. 471: 41-50. PMID: 32529498
- Gongronema latifolium leaf extract modulates hyperglycaemia, inhibits redox imbalance and inflammation in alloxan-induced diabetic nephropathy. | Ojo, OA., et al. 2020. J Diabetes Metab Disord. 19: 469-481. PMID: 32550199
- Structure and Reactivity of Alloxan Monohydrate in the Liquid Phase. | Bingham, JT., et al. 2021. J Org Chem. 86: 14553-14562. PMID: 34582209
- Anti-diabetogenic and in vivo antioxidant activity of ethanol extract of Dryopteris dilatata in alloxan-induced male Wistar rats. | Ajirioghene, AE., et al. 2021. Biomarkers. 26: 718-725. PMID: 34612093
- Effects of ibuprofen-loaded TiO₂ nanotube dental implants in alloxan-induced diabetic rabbits. | Kim, YG., et al. 2021. J Periodontal Implant Sci. 51: 352-363. PMID: 34713996
- In Vitro Role of Pumpkin Parts as Pharma-Foods: Antihyperglycemic and Antihyperlipidemic Activities of Pumpkin Peel, Flesh, and Seed Powders, in Alloxan-Induced Diabetic Rats. | Hussain, A., et al. 2022. Int J Food Sci. 2022: 4804408. PMID: 35959224
- Arabic gum ameliorates systemic modulation in Alloxan monohydrate-induced diabetic rats. | Ibrahim, RM., et al. 2023. Sci Rep. 13: 5005. PMID: 36973339
- Evaluation of Antidiabetic Activity of Oxadiazole Derivative in Rats. | Qazi, AI., et al. 2023. Evid Based Complement Alternat Med. 2023: 1141554. PMID: 37143509
- A new diabetes model induced by neonatal alloxan treatment in rats. | Kodama, T., et al. 1993. Diabetes Res Clin Pract. 20: 183-9. PMID: 8404451
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Alloxan monohydrate, 10 g | sc-254940 | 10 g | $54.00 |