Molecular structure of ALLN, CAS Number: 110044-82-1
ALLN (CAS 110044-82-1)
See product citations (20)
Alternate Names:
N-acetyl-Leu-Leu-Norleucinal; Calpain Inhibitor I
Application:
ALLN is a peptide aldehyde inhibitor of calpains and cathepsins
CAS Number:
110044-82-1
Molecular Weight:
383.53
Molecular Formula:
C20H37N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
ALLN, also known as Calpain Inhibitor I, is an inhibitor of Calpain 1(calpain I) (Ki = 190 nM), Calpain 2(calpain II) (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). It inhibits neutral cysteine proteases and proteasome (Ki = 6 muM). It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IkappaBalpha and IkappaBbeta by the ubiquitin-proteasome complex. ALLN also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
ALLN (CAS 110044-82-1) References
- Regulation of BRCA1 by protein degradation. | Blagosklonny, MV., et al. 1999. Oncogene. 18: 6460-8. PMID: 10597248
- The production of 85 kDa N-terminal fragment of apolipoprotein B in mutant HepG2 cells generated by targeted modification of apoB gene occurs by ALLN-inhibitable protease cleavage during translocation. | Srivastava, N., et al. 2010. Biochem Biophys Res Commun. 398: 665-70. PMID: 20609357
- [Analgesic effect of calpain inhibitor ALLN on the zymosan-induced paw inflammatory pain and its effect on the expression of cyclooxygenase-2 in the spinal dorsal horn]. | Wang, JJ., et al. 2012. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 34: 25-31. PMID: 22737715
- ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice. | Sebe, JY., et al. 2013. J Neurophysiol. 109: 429-36. PMID: 23100132
- Anti-malarial activity of new N-acetyl-L-leucyl-L-leucyl-L-norleucinal (ALLN) derivatives against Plasmodium falciparum. | Choi, HJ., et al. 2013. Bioorg Med Chem Lett. 23: 1293-6. PMID: 23357632
- Specific calpain activity evaluation in Plasmodium parasites. | Gomes, MM., et al. 2015. Anal Biochem. 468: 22-7. PMID: 25281458
- UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer. | Li, SZ., et al. 2014. Sci Rep. 4: 6910. PMID: 25376843
- The Toxic Effect of ALLN on Primary Rat Retinal Neurons. | Li, N., et al. 2016. Neurotox Res. 30: 392-406. PMID: 27194525
- Inhibition of calpain on oxygen glucose deprivation-induced RGC-5 necroptosis. | Chen, S., et al. 2016. J Huazhong Univ Sci Technolog Med Sci. 36: 639-645. PMID: 27752886
- The role and mechanism of chaperones Calnexin/Calreticulin in which ALLN selectively rescues the trafficking defective of HERG-A561V mutation. | Wang, Y., et al. 2018. Biosci Rep. 38: PMID: 29752336
- Effects of calpain inhibitor on the apoptosis of hepatic stellate cells induced by calcium ionophore A23187. | Li, Y., et al. 2019. J Cell Biochem. 120: 1685-1693. PMID: 30191626
- Loss-of-Function Piezo1 Mutations Display Altered Stability Driven by Ubiquitination and Proteasomal Degradation. | Zhou, Z., et al. 2021. Front Pharmacol. 12: 766416. PMID: 34867393
- Protective Effect of Calpain Inhibition During Cold Ischemia on Ischemia-reperfusion Injury After Lung Transplantation. | Matsui, Y., et al. 2023. Transplantation.. PMID: 36648297
Inhibitor of:
Apoptosis, Calpain, Calpain 1, Calpain 2, cathepsin B, and cathepsin L.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ALLN, 5 mg | sc-221236 | 5 mg | $134.00 |