Molecular structure of Allicin, CAS Number: 539-86-6
Allicin (CAS 539-86-6)
See product citations (7)
Alternate Names:
Allicin is also known as Diallyl thiosulfinate and Allylthiosulphinic acid allyl ester.
Application:
Allicin is a compound that exhibits anticancer, antioxidative, cardioprotective, antihypertensive, anti-arrhythmic, anti-parasitic, and anti-diabetic activities activity.
CAS Number:
539-86-6
Purity:
≥98%
Molecular Weight:
162.27
Molecular Formula:
C6H10OS2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Allicin is an thiocyanate found in garlic. It is unstable in aqueous solution without formic acid. Allicin rapidly decomposes mainly to diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DATS), and ajoene. DATS and DADS act as donors of H2S donors, which plays a cell signaling role similar to NO and CO. Allicin exhibits antimicrobial, antioxidant, antiproliferative, chemopreventive, antihyperlipidaemic and antihypertensive effects. Additionally, Allicin inhibits telomerase activity and inducible nitric oxide synthase (iNOS NOS II) expression and promotes apoptosis.
Allicin (CAS 539-86-6) References
- Antimicrobial properties of allicin from garlic. | Ankri, S. and Mirelman, D. 1999. Microbes Infect. 1: 125-9. PMID: 10594976
- The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats. | Elkayam, A., et al. 2001. Am J Hypertens. 14: 377-81. PMID: 11336185
- Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. | Hirsch, K., et al. 2000. Nutr Cancer. 38: 245-54. PMID: 11525603
- Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells. | Sun, L. and Wang, X. 2003. World J Gastroenterol. 9: 1930-4. PMID: 12970878
- Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. | Oommen, S., et al. 2004. Eur J Pharmacol. 485: 97-103. PMID: 14757128
- Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus. | Cutler, RR. and Wilson, P. 2004. Br J Biomed Sci. 61: 71-4. PMID: 15250668
- An overview of the antifungal properties of allicin and its breakdown products--the possibility of a safe and effective antifungal prophylactic. | Davis, SR. 2005. Mycoses. 48: 95-100. PMID: 15743425
- The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide. | Chung, LY. 2006. J Med Food. 9: 205-13. PMID: 16822206
- Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial. | Gardner, CD., et al. 2007. Arch Intern Med. 167: 346-53. PMID: 17325296
- Hydrogen sulfide mediates the vasoactivity of garlic. | Benavides, GA., et al. 2007. Proc Natl Acad Sci U S A. 104: 17977-82. PMID: 17951430
- Protective effect of allicin against gentamicin-induced nephrotoxicity in rats. | El-Kashef, DH., et al. 2015. Int Immunopharmacol. 29: 679-686. PMID: 26391062
- Allicin relaxes isolated mesenteric arteries through activation of PKA-KATP channel in rat. | Li, S., et al. 2017. J Recept Signal Transduct Res. 37: 17-24. PMID: 27049346
- Activation of the Nrf2 Signaling Pathway Involving KLF9 Plays a Critical Role in Allicin Resisting Against Arsenic Trioxide-Induced Hepatotoxicity in Rats. | Yang, D., et al. 2017. Biol Trace Elem Res. 176: 192-200. PMID: 27561292
- Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. | Ankri, S., et al. 1997. Antimicrob Agents Chemother. 41: 2286-8. PMID: 9333064
- Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase. | Dirsch, VM., et al. 1998. Atherosclerosis. 139: 333-9. PMID: 9712340
Inhibitor of:
ALS, CBP β, cystatin 9, cystatin SN, ELFN1, FER1L6, GSTT2, H2-Bl, H2-M9, HMG-2L1, Keg1, LACTB2, LOC100040299, Ly6G6c, LYZL2, NOS, Olfr324, OTTMUSG00000013284, OTTMUSG00000014862, OTTMUSG00000015173, OTTMUSG00000015220, OTTMUSG00000015279, OTTMUSG00000015337, OTTMUSG00000015417, OTTMUSG00000015643, OTTMUSG00000015752, PhyC, SPANX-B, TMPRSS11C, TPST-1, V1RC24, V1RC32, and V1rc5.Activator of:
9530003J23Rik, ANKTM1, apoA-IV, C20orf194, CES4, CYP2J6, CYP39A1, CYP4F8, CYP51A1, DnaJC5B, Helicobacter pylori HSP, KAT I, Klkb1, LDLRAD1, Lex A, MuRF3, PIG-M, Protein C, Sc5d, TFPI, TMPRSS11A, TRBV1, TRIM64B, and ZCWPW2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Allicin, 1 mg | sc-202449 | 1 mg | $460.00 | |||
Allicin, 5 mg | sc-202449A | 5 mg | $1428.00 |