Molecular structure of all-trans Retinoyl β-D-Glucuronide, CAS Number: 401-10-5
all-trans Retinoyl β-D-Glucuronide (CAS 401-10-5)
Alternate Names:
RAG
Application:
all-trans Retinoyl β-D-Glucuronide is a vitamin A metabolite shown to promote cell differentiation
CAS Number:
401-10-5
Molecular Weight:
476.56
Molecular Formula:
C26H36O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A biliary metabolite of Vitamin A. Occurs endogenously in human blood. RAG is biologically active in promoting the growth of vitamin A-deficient rats and the the induction of differentiation of HL-60 and BA-HAN-1C cells.
all-trans Retinoyl β-D-Glucuronide (CAS 401-10-5) References
- All-trans-retinoic acid and all-trans-retinoyl-beta-D-glucuronide alter the development of axolotl embryos (Ambystoma mexicanum) in vitro. | Krätke, R., et al. 2000. Arch Toxicol. 74: 173-80. PMID: 10877004
- Pharmacokinetic study of all-trans-retinoyl-beta-D-glucuronide in Sprague-Dawley rats after single and multiple intravenous administration(s). | Lin, HS., et al. 2001. J Pharm Sci. 90: 2023-31. PMID: 11745761
- Effects of all-trans-retinoic acid and all-trans-retinoyl glucuronide in two in vitro systems of distinct biological complexity. | Rühl, R., et al. 2001. Arch Toxicol. 75: 497-504. PMID: 11757674
- Repeated intravenous doses of all-trans-retinoyl beta-D-glucuronide is not effective in the treatment of bacterial bronchopneumonia in lambs but is devoid of gross and acute toxicity. | Gallup, JM., et al. 2002. Med Sci Monit. 8: BR345-53. PMID: 12218935
- RETINOYL BETA-GLUCURONIC ACID: A MAJOR METABOLITE OF VITAMIN A IN RAT BILE. | DUNAGIN, PE., et al. 1965. Science. 148: 86-7. PMID: 14258729
- Comparative studies on effects of all-trans-retinoic acid and all-trans-retinoyl-beta-d-glucuronide on the development of foetal mouse thymus in an organ culture system. | Foerster, M., et al. 1996. Toxicol In Vitro. 10: 7-15. PMID: 20650177
- Biosynthesis of beta-glucuronides of retinol and of retinoic acid in vivo and in vitro. | Lippel, K. and Olson, JA. 1968. J Lipid Res. 9: 168-75. PMID: 4295866
- All-trans-retinoyl-beta-glucuronide is a potent teratogen in the mouse because of extensive metabolism to all-trans-retinoic acid. | Nau, H., et al. 1996. Teratology. 54: 150-6. PMID: 8987158
- Effects of all-trans-retinoyl-beta-D-glucuronide and all-trans-retinoic acid on chondrogenesis and retinoid metabolism in mouse limb bud mesenchymal cells in vitro. | Sass, JO., et al. 1997. Arch Toxicol. 71: 142-50. PMID: 9049050
- Retinoid signaling by all-trans retinoic acid and all-trans retinoyl-beta-D-glucuronide is attenuated by simultaneous exposure of human keratinocytes to retinol. | Zouboulis, CC., et al. 1999. J Invest Dermatol. 112: 157-64. PMID: 9989790
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
all-trans Retinoyl β-D-Glucuronide, 1 mg | sc-221235A | 1 mg | $595.00 | |||
all-trans Retinoyl β-D-Glucuronide, 10 mg | sc-221235 | 10 mg | $2129.00 |