Molecular structure of all-trans-Anhydro Retinol
all-trans-Anhydro Retinol (CAS 1224-78-8)
Alternate Names:
Anhydroretinol; Anhydrovitamin A
Application:
all-trans-Anhydro Retinol is a metabolite of vitamin A (Retinol)
CAS Number:
1224-78-8
Molecular Weight:
268.44
Molecular Formula:
C20H28
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
all-trans-Anhydro Retinol plays a pivotal role in diverse scientific research applications. Primarily utilized in cell culture studies, it serves as a component for investigating the impact of retinoid signaling on gene expression and cell differentiation. The conversion of retinol to its active state, retinoic acid, is facilitated by the enzyme Anhydrovitamin A dehydrogenase. Subsequently, retinoic acid engages with nuclear receptors, specifically retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Through this interaction, gene expression is either activated or repressed, contingent upon the receptor type and the specific gene being regulated.
all-trans-Anhydro Retinol (CAS 1224-78-8) References
- Anhydroretinol induces oxidative stress and cell death. | Chen, Y., et al. 1999. Cancer Res. 59: 3985-90. PMID: 10463596
- Teratogenicity, tissue distribution, and metabolism of the retro-retinoids, 14-hydroxy-4,14-retro-retinol and anhydroretinol, in the C57BL/6J mouse. | Mao, GE., et al. 2000. Toxicol Appl Pharmacol. 163: 38-49. PMID: 10662603
- A retinyl palmitate model of the phenomenon of the intrinsic fluorescence increase in ceroid-lipofuscin cytosomes. | Tatariunas, A. and Matsumoto, S. 2000. Exp Gerontol. 35: 1327-41. PMID: 11113611
- A helical lid converts a sulfotransferase to a dehydratase. | Pakhomova, S., et al. 2001. Nat Struct Biol. 8: 447-51. PMID: 11323722
- Photomutagenicity of anhydroretinol and 5,6-epoxyretinyl palmitate in mouse lymphoma cells. | Mei, N., et al. 2006. Chem Res Toxicol. 19: 1435-40. PMID: 17112230
- UVA photoirradiation of anhydroretinol--formation of singlet oxygen and superoxide. | Yin, JJ., et al. 2007. Toxicol Ind Health. 23: 625-31. PMID: 18717521
- Effect of retinoids on growth factor-induced anchorage independent growth of human fibroblasts. | Palmer, HJ., et al. 1989. In Vitro Cell Dev Biol. 25: 1009-15. PMID: 2592294
- Microgels for long-term storage of vitamins for extended spaceflight. | Schroeder, R. 2018. Life Sci Space Res (Amst). 16: 26-37. PMID: 29475517
- Microencapsulated Vitamin A Palmitate Degradation Mechanism Study To Improve the Product Stability. | Xu, M. and Watson, J. 2021. J Agric Food Chem. 69: 15681-15690. PMID: 34928147
- Retinoid metabolism in spontaneously transformed mouse fibroblasts (Balb/c 3T12-3 cells): enzymatic conversion of retinol to anhydroretinol. | Bhat, PV., et al. 1979. J Lipid Res. 20: 357-62. PMID: 448240
- Analysis of deuterated analogs of vitamin A by electron impact and chemical ionization modes in gas chromatography coupled to mass spectrometry. | Cullum, ME., et al. 1984. Int J Vitam Nutr Res. 54: 3-10. PMID: 6735613
- The biosynthesis of a mannolipid containing a metabolite of retinoic acid by 3T12 mouse fibroblasts. | Bhat, PV. and De Luca, LM. 1981. Ann N Y Acad Sci. 359: 135-49. PMID: 6942671
- Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology. | Buck, J., et al. 1993. J Exp Med. 178: 675-80. PMID: 8340762
- Purification, cloning, and bacterial expression of retinol dehydratase from Spodoptera frugiperda. | Grün, F., et al. 1996. J Biol Chem. 271: 16135-8. PMID: 8663216
- Extraction of human epidermis treated with retinol yields retro-retinoids in addition to free retinol and retinyl esters. | Duell, EA., et al. 1996. J Invest Dermatol. 107: 178-82. PMID: 8757759
- Anhydroretinol, a retinoid active in preventing mammary cancer induced in rats by N-methyl-N-nitrosourea. | Shealy, YF., et al. 1998. Oncol Rep. 5: 857-60. PMID: 9625832
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
all-trans-Anhydro Retinol, 50 mg | sc-396043 | 50 mg | $618.00 |