Molecular structure of all-trans-3,4-Didehydro Retinoic Acid, CAS Number: 4159-20-0
all-trans-3,4-Didehydro Retinoic Acid (CAS 4159-20-0)
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Alternate Names:
all-trans-Vitamin A2 Acid; (all-E)-3,7-dimethyl-9-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2,4,6,8-nonatetraenoic acid; 3-Dehydroretinoic acid
CAS Number:
4159-20-0
Molecular Weight:
298.42
Molecular Formula:
C20H26O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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all-trans-3,4-Didehydro Retinoic Acid, also known as 3,4-Didehydroretinoic acid (3,4-DHRA), is an organic substance found in nature and obtained from retinol, known as vitamin A. This powerful synthetic retinoid is extensively employed in laboratory investigations to examine the impact of retinoid-based compounds on biological systems. Researchers hypothesize that its mechanism involves attaching to the retinoic acid receptor (RAR). The binding of all-trans-3,4-Didehydro Retinoic Acid to RAR triggers the activation of the receptor, resulting in alterations in gene expression as well as various biochemical and physiological effects.
all-trans-3,4-Didehydro Retinoic Acid (CAS 4159-20-0) References
- Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally. | Ulven, SM., et al. 2001. Dev Dyn. 222: 341-53. PMID: 11747070
- Retinoids: essential nutrients for the central nervous system. | Blomhoff, R. 2002. Nutr Health. 16: 35-9. PMID: 12083410
- Delayed effects of pre- and early-life time exposure to polychlorinated biphenyls on tadpoles of two amphibian species (Xenopus laevis and Rana temporaria). | Gutleb, AC., et al. 1999. Environ Toxicol Pharmacol. 8: 1-14. PMID: 21781936
- Consequences of metal exposure on retinoid metabolism in vertebrates: a review. | Defo, MA., et al. 2014. Toxicol Lett. 225: 1-11. PMID: 24291063
- Glochidion littorale Leaf Extract Exhibits Neuroprotective Effects in Caenorhabditis elegans via DAF-16 Activation. | Bagoudou, AF., et al. 2021. Molecules. 26: PMID: 34203560
- Triple chemical derivatization strategy assisted liquid chromatography-mass spectrometry for determination of retinoic acids in human serum. | Gong, GG., et al. 2022. Talanta. 245: 123474. PMID: 35462137
- Retinoid signalling and axial patterning during early vertebrate embryogenesis. | Durston, AJ., et al. 1997. Cell Mol Life Sci. 53: 339-49. PMID: 9137625
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
all-trans-3,4-Didehydro Retinoic Acid, 2.5 mg | sc-500519 | 2.5 mg | $354.00 | |||
all-trans-3,4-Didehydro Retinoic Acid, 25 mg | sc-500519A | 25 mg | $2497.00 |