Molecular structure of ALK5 Inhibitor II, CAS Number: 446859-33-2
ALK5 Inhibitor II (CAS 446859-33-2)
See product citations (8)
Alternate Names:
ALK5 Inhibitor II is also known as RepSox, TGF-&beta, and RI Kinase Inhibitor II.
Application:
ALK5 Inhibitor II is an ATP-competitive inhibitor of TGF-β RI kinase and has been used as an to inhibit autophosphorylation of ALK5.
CAS Number:
446859-33-2
Purity:
≥97%
Molecular Weight:
287.32
Molecular Formula:
C17H13N5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ALK5 Inhibitor II is a cell permeable, potent, selective and ATP-competitive inhibitor of TGF-beta RI kinase (IC50=23nM, 4nM and 18nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-beta RI kinase, respectively). TGF beta RI (ALK5) Inhibitor II affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16muM), minimally. ALK5 Inhibitor II has also been used as a basal media component for culturing human Pluripotent stem cells.
ALK5 Inhibitor II (CAS 446859-33-2) References
- Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. | Gellibert, F., et al. 2004. J Med Chem. 47: 4494-506. PMID: 15317461
- A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. | Ichida, JK., et al. 2009. Cell Stem Cell. 5: 491-503. PMID: 19818703
- Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture. | Takeuchi, H., et al. 2014. Sci Rep. 4: 4488. PMID: 24671046
- Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway. | Blum, B., et al. 2014. Elife. 3: e02809. PMID: 25233132
- MicroRNA-223 is essential for maintaining functional β-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways. | Li, Y., et al. 2019. J Biol Chem. 294: 10438-10448. PMID: 31118273
- Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in vitro. | Bakhti, M., et al. 2019. Mol Metab. 30: 16-29. PMID: 31767167
- Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling. | Shrestha, N., et al. 2020. J Clin Invest. 130: 3499-3510. PMID: 32182217
- Bioinformatic Analyses of miRNA-mRNA Signature during hiPSC Differentiation towards Insulin-Producing Cells upon HNF4α Mutation. | Ghila, L., et al. 2020. Biomedicines. 8: PMID: 32605028
- Immune-evasive human islet-like organoids ameliorate diabetes. | Yoshihara, E., et al. 2020. Nature. 586: 606-611. PMID: 32814902
- Dual inhibition of TGFβR and ROCK reverses the epithelial to mesenchymal transition in collectively migrating zebrafish keratocytes. | Pascual, AS., et al. 2021. Cell Biol Int. 45: 1288-1295. PMID: 33710707
- Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians. | Nair, AK., et al. 2022. Cells. 11: PMID: 35563754
- TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation. | Li, J., et al. 2022. Nat Commun. 13: 3907. PMID: 35798741
- Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. | Mattis, KK., et al. 2023. Diabetologia. 66: 674-694. PMID: 36633628
Inhibitor of:
β ig-h3, ACTR-IA, ACTR-IB, ACTR-IIA, ACTR-IIB, ADMP, AHNAK, Asporin, BMP-4, BMPR-IB, CRIM1, Cryptic, DAF-1, Dppa1, dsg1α, FAM75A1, FAST-1/2, FGL1, FHL-2, FLRG, Fussel-18, GDF-1, GDF-3, GDF-5, GDF-7, GDF-9, GDF-9B, gremlin-1, gremlin-2, Hepcidin, Hic-5, IL-3Rβ, Inhibin β-A, Inhibin β-E, Integrin β8, LOC645323, LOC645781, LOC646862, LRP4, LRRC32, LRRC70, LRRC72, Lumican, M-RIP, MAWDBP1, MKX, netrin-1, Nodal, NOMO, NOMO1, NOMO2, NOMO3, NPN, Oct-6, PLAGL2, PMEPA1, POU3F, PTGF-β, SARA, Ski, Sm B/B′, Smad2, Smad3, Smad4, Smad5, Smad6, Smad7, Smad8, SNIP1, SOX (SRY-box transcription factor), Sox-10, Sox-21, Sox-22, Sox-6, TBCK, TBX22, TGF B3, TGF beta, TGF beta 1, TGF beta RI, TGFα, TGFβ RIII, TGIF2LX1, TGIF2LX2, Thrombospondin 4, TIAF-1, TIMAP, Trichohyalin, and Vasorin.Activator of:
ADMP, BMP-5, CCDC43, CCDC49, CD109, COL27A1, COL2A1, Cytokeratin 12, DAF-3, DAF-7, DAND5, dpp, ECM2, fibrillin-3, GDF-1, GDF-11, Id4, Inhibin β-B, Keratin 17, Lefty-2, MAWDBP1, SnoN_SnoN2_SnoA, SSEA-4, TGF B-1, TGF B3, TGIF, TGIF2LX, TGIF2LY, TMEM100, TSC-22 D2, TSC-36, WFIKKN, ZNF512, and ZNF512B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ALK5 Inhibitor II, 1 mg | sc-221234 | 1 mg | $75.00 | |||
ALK5 Inhibitor II, 5 mg | sc-221234A | 5 mg | $150.00 | |||
ALK5 Inhibitor II, 10 mg | sc-221234B | 10 mg | $215.00 | |||
ALK5 Inhibitor II, 50 mg | sc-221234C | 50 mg | $650.00 | |||
ALK5 Inhibitor II, 100 mg | sc-221234D | 100 mg | $1224.00 | |||
ALK5 Inhibitor II, 500 mg | sc-221234E | 500 mg | $4296.00 | |||
ALK5 Inhibitor II, 1 g | sc-221234F | 1 g | $7818.00 |