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Alizarin Red S (CAS 130-22-3)

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Alternate Names:
Sodium Alizarinesulfonate; Mordant Red 3; Alizarin Carmine
Application:
Alizarin Red S is used to determine the presence of calcific deposition by cells of an osteogenic lineage
CAS Number:
130-22-3
Molecular Weight:
342.26
Molecular Formula:
C14H7O7S•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Alizarin Red S, identified by the CAS number 130-22-3, is an anthraquinone dye known for its deep red color and extensive utility in biological and geological research applications, distinct from any medical or pharmaceutical uses. This chemical primarily functions through chelation, a process where it forms complexes with divalent metal ions, notably calcium. Such a mechanism is crucial in its popular use in the staining of calcified structures, making it invaluable in both histological and archaeological studies to detect and visualize calcium deposits in tissues or other samples. In research contexts, Alizarin Red S is employed to stain mineralized tissues red, which is particularly useful in studies of bone growth, bone healing, and the development of bone-related pathologies. This application extends to the field of paleontology where it is used to identify and highlight calcified elements in fossil specimens. The dye′s ability to bind calcium ions and form complexes that exhibit a marked red color under microscopic analysis also makes it a tool in the study of biomineralization processes. This has further implications in understanding geological formations where calcium presence is significant, thereby bridging disciplines by its versatile staining applications that enhance the visualization of calcium-rich structures in varied scientific inquiries.


Alizarin Red S (CAS 130-22-3) References

  1. Leptin increases growth of primary ossification centers in fetal mice.  |  Bertoni, L., et al. 2009. J Anat. 215: 577-83. PMID: 19682137
  2. Osteoblast adhesion, proliferation and growth on polyelectrolyte complex-hydroxyapatite nanocomposites.  |  Verma, D., et al. 2010. Philos Trans A Math Phys Eng Sci. 368: 2083-97. PMID: 20308116
  3. Identification of Periostin Positive Cell Population during the Long-Term Culture of Mouse Tendon-Derived Cells in Late Passage.  |  Wu, YF., et al. 2024. Stem Cells Dev.. PMID: 38676599
  4. Enhanced osteogenic differentiation potential of Arnica montana and Bellis perennis in C3H10T1/2 multipotent mesenchymal stem cells.  |  Deepika, BK., et al. 2024. Mol Biol Rep. 51: 596. PMID: 38683461
  5. Enhancing photocatalytic wastewater treatment: investigating the promising applications of nickel ferrite and its novel nanocomposites.  |  Anjaneyulu, B., et al. 2024. Environ Sci Pollut Res Int.. PMID: 38684612
  6. Water-soluble biopolymers calcium polymalate derived from fermentation broth of Aureobasidium pullulans markedly alleviates osteoporosis and fatigue.  |  Li, F., et al. 2024. Int J Biol Macromol. 268: 132013. PMID: 38697412
  7. Vaspin facilitates the proliferation and osteogenic differentiation of periodontal ligament stem cells.  |  Jing, Z., et al. 2024. J Periodontal Res.. PMID: 38699861
  8. A GMP-compliant manufacturing method for Wharton's jelly-derived mesenchymal stromal cells.  |  Chu, W., et al. 2024. Stem Cell Res Ther. 15: 131. PMID: 38702793
  9. Mild Thermotherapy-Assisted GelMA/HA/MPDA@Roxadustat 3D-Printed Scaffolds with Combined Angiogenesis-Osteogenesis Functions for Bone Regeneration.  |  You, J., et al. 2024. Adv Healthc Mater. e2400545. PMID: 38706444
  10. Designing and synthesis of injectable hydrogel based on carboxymethyl cellulose/carboxymethyl chitosan containing QK peptide for femoral head osteonecrosis healing.  |  Peyravian, N., et al. 2024. Int J Biol Macromol. 270: 132127. PMID: 38718991

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Alizarin Red S, 25 g

sc-205998
25 g
$92.00

Alizarin Red S, 100 g

sc-205998A
100 g
$200.00

Alizarin Red S, 250 g

sc-205998B
250 g
$465.00

Alizarin Red S, 1 kg

sc-205998C
1 kg
$1230.00

Hi, please advise the availability of ALIZARIN RED S 25g, in stock, lag time .

Asked by: Xingting
Thank you for your question. For accurate availability, shipping and pricing information regarding our chemical products, please contact Customer Service.
Answered by: Tech Service
Date published: 2019-08-20
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Rated 5 out of 5 by from Various publications cite the use of AlizarinVarious publications cite the use of Alizarin Red S in biochemical assays to determine, quantitatively by colorimetry, the presence of calcific deposition by cells of an osteogenic lineage. Alizarin Red S has also been used as a histochemical stain for calcium in cells of non-osteogenic lineage and also a colorometric pH indicator in the range of 3.8-5.4. -SCBT Publication Review
Date published: 2015-03-19
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Alizarin Red S is rated 5.0 out of 5 by 1.
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