Aliskiren Hydrochloride CAS: 173399-03-6
MF: C30H53N3O6•HCl
MW: 588.22
A synthetic non-pepetide renin inhibitor.

Aliskiren Hydrochloride (CAS 173399-03-6)

Aliskiren Hydrochloride | CAS 173399-03-6 is rated 5.0 out of 5 by 1.
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Synonym: Rasilez Hydrochloride; Tekturna Hydrochloride; SPP 100
Application: A synthetic non-pepetide renin inhibitor
CAS Number: 173399-03-6
Molecular Weight: 588.22
Molecular Formula: C30H53N3O6•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Aliskiren hydrochloride is a direct renin inhibitor with an IC50 = 0.72 nM. Renin is the first enzyme in the renin-angiotensin-aldosterone system (RAAS) and cleaves angiotensinogen, an inactive peptide, into angiotensin I. Inhibition of renin prevents this cleavage and subsequent activiation of angiotensin II receptors.


References

Lefevre, G., et al.: J. Immunoassay, 21, 65 (2000), Allikments, K., et al.: Curr. Opin. Invest. Drugs, 3, 1479 (2002), Wood, J.M., et al.: Biochem. Biophys. Res. Commun., 308, 698 (2003), Grandman, A.H., et al.: Circulation, 111, 1012 (2005),

Physical State :
Solid
Solubility :
Soluble in methanol, chloroform, and water.
Storage :
Store at -20° C
Melting Point :
76-78° C
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
Renin: IC50 = 0.6 nM (human); Cathepsin E: IC50 >10 µM (human); Cathepsin D: IC50 >10 µM (human); Pepsin A: IC50 >10 µM (human); Beta-secretase 1: IC50 >10 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DA6613500
PubChem CID :
23625795
MDL Number :
MFCD13185885
SMILES :
CC(C)[[email protected]@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[[email protected]@H]([[email protected]](C[[email protected]@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Relevant assays for usage as analytical standards Relevant assays for usage as analytical standards.
Date published: 2015-06-08
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