Date published: 2025-11-6

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Alendronate sodium (CAS 129318-43-0)

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Alternate Names:
Fosamax
CAS Number:
129318-43-0
Purity:
≥95%
Molecular Weight:
271.08
Molecular Formula:
C4H12NNaO7P2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Alendronate sodium is a bisphosphonate compound widely studied in the field of materials science and biochemistry for its affinity to calcium and its ability to bind to hydroxyapatite, the mineral component of bone. Research applications often focus on the mechanisms by which alendronate sodium interacts with bone mineral at the molecular level, exploring its potential to influence mineralization processes. Investigations also delve into its role in the regulation of osteoclast-mediated bone resorption, which is significant for understanding bone turnover and metabolism. Additionally, alendronate sodium is used as a tool in the study of conditions characterized by altered bone density and quality. In materials science, the compound′s strong affinity for calcium makes it a candidate for the development of novel coatings and for the stabilization of bioceramics.


Alendronate sodium (CAS 129318-43-0) References

  1. The effect of alendronate sodium on human erythrocytes.  |  Kopka, A., et al. 2011. Environ Toxicol Pharmacol. 32: 306-14. PMID: 21843812
  2. Alendronate sodium.  |  Ananchenko, G., et al. 2013. Profiles Drug Subst Excip Relat Methodol. 38: 1-33. PMID: 23668401
  3. Important aspects concerning alendronate-related osteonecrosis of the jaws: a literature review.  |  Iglesias, JE., et al. 2015. Gerodontology. 32: 169-78. PMID: 24256517
  4. Effect of alendronate sodium on tooth movement in ovariectomized rats.  |  Salazar, M., et al. 2015. Arch Oral Biol. 60: 776-81. PMID: 25766470
  5. Alendronate Sodium as Enteric Coated Solid Lipid Nanoparticles; Preparation, Optimization, and In Vivo Evaluation to Enhance Its Oral Bioavailability.  |  Hosny, KM. 2016. PLoS One. 11: e0154926. PMID: 27148747
  6. Zoledronic acid and alendronate sodium and the implications in orthodontic movement.  |  Franzoni, JS., et al. 2017. Orthod Craniofac Res. 20: 164-169. PMID: 28653350
  7. Calcifediol (25-hydroxyvitamin D) improvement and calcium-phosphate metabolism of alendronate sodium/vitamin D3 combination in Chinese women with postmenopausal osteoporosis: a post hoc efficacy analysis and safety reappraisal.  |  Liao, EY., et al. 2018. BMC Musculoskelet Disord. 19: 210. PMID: 29970059
  8. Evaluating two nanocarrier systems for the transdermal delivery of sodium alendronate.  |  Villanueva-Martínez, A., et al. 2020. Int J Pharm. 582: 119312. PMID: 32278052
  9. Microtomographic analysis of the effect of sodium alendronate on orthodontic movement in rats.  |  Lopes, LLA., et al. 2021. Orthod Craniofac Res. 24: 96-101. PMID: 32639673
  10. Topical sodium alendronate combined or not with photodynamic therapy as an adjunct to scaling and root planing: Histochemical and immunohistochemical study in rats.  |  Santinoni, CS., et al. 2020. J Periodontal Res. 55: 850-858. PMID: 32648296
  11. Wasp venom peptide improves the proapoptotic activity of alendronate sodium in A549 lung cancer cells.  |  Alhakamy, NA., et al. 2022. PLoS One. 17: e0264093. PMID: 35202419
  12. Alendronate sodium-polymeric nanoparticles display low toxicity in gastric mucosal of rats and Ofcol II cells.  |  Iles, B., et al. 2021. NanoImpact. 24: 100355. PMID: 35559814
  13. Preparation and evaluation of alendronate sodium solid lipid nanoparticles with high oral bioavailability in rats.  |  Geng, R., et al. 2022. Pak J Pharm Sci. 35: 493-499. PMID: 35642405
  14. NH2-MIL-101(Fe) nanozyme-based dual-modality sensor for determination of alendronate sodium and study of two-dimensional correlation spectroscopy.  |  Chu, B., et al. 2022. Spectrochim Acta A Mol Biomol Spectrosc. 283: 121752. PMID: 35988469

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Alendronate sodium, 500 mg

sc-300175
500 mg
$102.00

Alendronate sodium, 1 g

sc-300175A
1 g
$153.00