Molecular structure of Aldosterone, CAS Number: 52-39-1
Aldosterone (CAS 52-39-1)
See product citations (1)
Alternate Names:
18-Aldocorticosterone; Reichstein X
Application:
Aldosterone is a MCR (mineralocorticoid receptor)
CAS Number:
52-39-1
Purity:
98%
Molecular Weight:
360.44
Molecular Formula:
C21H28O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Aldosterone is a hormone analog reported to be involved in sodium balance regulation. This compound has been noted to specifically activate MCR (mineralocorticoid receptor, MR), resulting in induction of O2- production via upregulation of Nox-2, Nox-4, and Cox-2. The oxidative and inflammatory results of aldosterone have been shown to affect glucose metabolism. It influences the balance of water, sodium, and potassium. As the primary mineralocorticoid hormone, aldosterone exerts its effects through the mineralocorticoid receptor.
Aldosterone (CAS 52-39-1) References
- Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. | Masilamani, S., et al. 1999. J Clin Invest. 104: R19-23. PMID: 10510339
- Cardiac aldosterone production in genetically hypertensive rats. | Takeda, Y., et al. 2000. Hypertension. 36: 495-500. PMID: 11040225
- Aldosterone induces a vascular inflammatory phenotype in the rat heart. | Rocha, R., et al. 2002. Am J Physiol Heart Circ Physiol. 283: H1802-10. PMID: 12384457
- Aldosterone-induced inflammation in the rat heart : role of oxidative stress. | Sun, Y., et al. 2002. Am J Pathol. 161: 1773-81. PMID: 12414524
- Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. | Blasi, ER., et al. 2003. Kidney Int. 63: 1791-800. PMID: 12675855
- Action of new steroids in blocking effects of aldosterone and desoxycorticosterone on salt. | KAGAWA, CM., et al. 1957. Science. 126: 1015-6. PMID: 13486053
- Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics. | Chen, L., et al. 2004. J Am Chem Soc. 126: 7462-3. PMID: 15198592
- Ramoplanin: a lipoglycodepsipeptide antibiotic. | Farver, DK., et al. 2005. Ann Pharmacother. 39: 863-8. PMID: 15784805
- The mechanism of action of ramoplanin and enduracidin. | Fang, X., et al. 2006. Mol Biosyst. 2: 69-76. PMID: 16880924
- Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent. | Fulco, P. and Wenzel, RP. 2006. Expert Rev Anti Infect Ther. 4: 939-45. PMID: 17181409
- Rise in plasma concentration of aldosterone during long-term angiotensin II suppression. | Staessen, J., et al. 1981. J Endocrinol. 91: 457-65. PMID: 7035596
- Production of aldosterone in isolated rat blood vessels. | Takeda, Y., et al. 1995. Hypertension. 25: 170-3. PMID: 7843766
- Myocardial production of aldosterone and corticosterone in the rat. Physiological regulation. | Silvestre, JS., et al. 1998. J Biol Chem. 273: 4883-91. PMID: 9478930
Inhibitor of:
B230216G23Rik, and Na+ CP type IIβ.Activator of:
αENaC, βENaC, AbdA, ACE, Ace3, AKR1D1, Angiotensinase C, AQP2, ATP1AL1, BNP, DAZL, FXYD2, FXYD4, Gm694, KLHL3, L-type Ca++ CP β4, MCR, megsin, mPRβ, MRAP2, Myotrophin, Na+/K+-ATPase β1, Na+/K+-ATPase β2, Na+/K+-ATPase β3, NCC, NHE-1, NHE-11, NHE-3, NHEDC2, NKCC2, Pendrin, Pneumadin, Prostasin, ROM-K, SLC4A4, sodium/potassium-ATPase β1, SULT2B10, TMIE, TRMP6, TXNDC16, UT-A, and V2R11.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aldosterone, 2 mg | sc-210774 | 2 mg | $259.00 | |||
Aldosterone, 5 mg | sc-210774A | 5 mg | $213.00 | |||
Aldosterone, 10 mg | sc-210774B | 10 mg | $317.00 | |||
Aldosterone, 50 mg | sc-210774C | 50 mg | $1550.00 | |||
Aldosterone, 100 mg | sc-210774D | 100 mg | $3074.00 | |||
Aldosterone, 250 mg | sc-210774E | 250 mg | $7637.00 |