Aldehyde dehydrogenase 18-A1/ALDH18A1 Antibody (QQ19): sc-100498

ALDH18A1 Antibody (QQ19) is a mouse monoclonal IgG2b antibody that detects ALDH18A1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). ALDH18A1, also known as glutamate gamma-semialdehyde synthetase or Delta1-pyrroline-5-carboxylate synthetase, plays a crucial role in the biosynthesis of proline, arginine, and ornithine, which are essential amino acids involved in various metabolic processes. ALDH18A1 is primarily localized to the inner mitochondrial membrane, where ALDH18A1 catalyzes the conversion of glutamate to Delta1-pyrroline-5-carboxylate, a key intermediate in proline metabolism. This localization contributes to mitochondrial function and energy production, as proline is vital for cellular respiration and the synthesis of other important biomolecules. Additionally, ALDH18A1 undergoes alternative splicing, resulting in two isoforms that differ by only two amino acids; the longer isoform is widely expressed, while the shorter isoform is predominantly found in the gut. Mutations in the gene encoding ALDH18A1 can lead to P5CS deficiency, a condition marked by progressive joint laxity, neurodegeneration, bilateral subcapsular cataracts, and skin hyperelasticity, underscoring ALDH18A1′s significance in human health. Anti-ALDH18A1 antibody (QQ19) serves as an invaluable tool for researchers studying the functional implications of this enzyme in various biological contexts.

The preferred Aldehyde dehydrogenase 18-A1/ALDH18A1 antibody is Aldehyde dehydrogenase 18-A1/ALDH18A1 Antibody (G-10): sc-515443.