Molecular structure of Albofungin
Albofungin (CAS 37895-35-5)
Alternate Names:
Kanchanomycin
Application:
Albofungin is a polyaromatic heterocycle containing a N-aminoamide with a broad biological profile
CAS Number:
37895-35-5
Purity:
>95%
Molecular Weight:
520.49
Molecular Formula:
C27H24N2O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Albofungin is a compound that functions as an antifungal agent. It inhibits the growth of fungi by interfering with the synthesis of nucleic acids by binding to DNA and preventing transcription and replication. This disruption of nucleic acid synthesis ultimately leads to the inhibition of fungal cell growth and proliferation. Albofungin exerts its mode of action by targeting the fungal cells, disrupting their ability to replicate and causing them to die off. Albofungin′s mechanism of action involves its ability to bind to DNA and interfere with essential cellular processes, ultimately leading to the inhibition of fungal growth.
Albofungin (CAS 37895-35-5) References
- Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase. | Wu, WS., et al. 2018. J Am Chem Soc. 140: 2752-2755. PMID: 29411975
- Albofungin and chloroalbofungin: antibiotic crystals with 2D but not 3D isostructurality. | Ye, W., et al. 2020. Acta Crystallogr C Struct Chem. 76: 1100-1107. PMID: 33273148
- Discovery, Bioactivity Evaluation, Biosynthetic Gene Cluster Identification, and Heterologous Expression of Novel Albofungin Derivatives. | She, W., et al. 2021. Front Microbiol. 12: 635268. PMID: 33633715
- Structure of cervinomycin, a novel xantone antibiotic active against anaerobe and mycoplasma. | Nakagawa, A., et al. 1987. J Antibiot (Tokyo). 40: 301-8. PMID: 3570983
- Discovery, Yield Improvement, and Application in Marine Coatings of Potent Antifouling Compounds Albofungins Targeting Multiple Fouling Organisms. | She, W., et al. 2022. Front Microbiol. 13: 906345. PMID: 35875539
- Proteomining-Based Elucidation of Natural Product Biosynthetic Pathways in Streptomyces. | Linardi, D., et al. 2022. Front Microbiol. 13: 913756. PMID: 35898901
- Genetic and Biochemical Characterization of Halogenation and Drug Transportation Genes Encoded in the Albofungin Biosynthetic Gene Cluster. | Wang, ZC., et al. 2022. Appl Environ Microbiol. 88: e0080622. PMID: 36000868
- Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation. | Yang, C., et al. 2022. Nat Commun. 13: 5386. PMID: 36104338
- Identity of antibiotic P-42-1 elaborated by Actinomyces tumemacerans with kanchanomycin and albofungin. | Fukushima, K., et al. 1973. J Antibiot (Tokyo). 26: 65-9. PMID: 4781285
- Interaction of kanchanomycin with nucleic acids. 3. Contrasts in the mechanisms of inhibition of ribonucleic acid and deoxyribonucleic acid polymerase reactions. | Joel, PB., et al. 1970. Biochemistry. 9: 4421-7. PMID: 4919546
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Albofungin, 1 mg | sc-391725 | 1 mg | $292.00 |