AL 8810 ethyl amide
Molecular Weight:
429.57
Molecular Formula:
C26H36FNO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
An analog of AL 8810 in which the C-1 carboxyl group has been modified to an N-ethyl amide. This modification is analogous to the PG N-ethyl amides, as typified by Bimatoprost, that have been introduced as alternative PG ocular hypotensive prodrugs.2 In contrast to AL 8810 which contracted the cat iris, AL 8810 ethyl amide showed no contraction activity at concentrations up to 10-4 M and did not antagonize the activity of PGF2α-ethanolamide in this system.3
AL 8810 ethyl amide References
- AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor. | Griffin, BW., et al. 1999. J Pharmacol Exp Ther. 290: 1278-84. PMID: 10454504
- The pharmacology of bimatoprost (Lumigan). | Woodward, DF., et al. 2001. Surv Ophthalmol. 45 Suppl 4: S337-45. PMID: 11434936
- Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin-ethanolamides) in the feline iris. | Woodward, DF., et al. 2007. Br J Pharmacol. 150: 342-52. PMID: 17179945
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AL 8810 ethyl amide, 1 mg | sc-221232 | 1 mg | $80.00 | |||
AL 8810 ethyl amide, 5 mg | sc-221232A | 5 mg | $360.00 |