Molecular structure of AL 8810, CAS Number: 246246-19-5
AL 8810 (CAS 246246-19-5)
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Application:
AL 8810 is an 11β-fluoro analog of PGF2α which acts as a potent antagonist at the FP receptor
CAS Number:
246246-19-5
Purity:
≥98%
Molecular Weight:
402.50
Molecular Formula:
C24H31O4F
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AL 8810 is an 11β-fluoro analog of PGF2α which acts as a potent and selective antagonist at the FP receptor.1 AL 8810 has weak intrinsic agonist activity on FP receptor preparations in the 200-300 nM range, yet it fully antagonizes the activity of the potent FP receptor agonist fluprostenol at this concentration, with EC50 values of approximately 430 nM. AL 8810 fully antagonized the bimatoprost-induced calcium mobilization in Swiss 3T3 fibroblasts at 100 µM, indicating that bimatoprost acts as an FP agonist in this preparation.2 The Ki for the inhibition of several potent agonists at the cloned human ciliary body FP receptor is in the range of 1-2 µM.3
AL 8810 (CAS 246246-19-5) References
- AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor. | Griffin, BW., et al. 1999. J Pharmacol Exp Ther. 290: 1278-84. PMID: 10454504
- Insulin induces airway smooth muscle contraction. | Schaafsma, D., et al. 2007. Br J Pharmacol. 150: 136-42. PMID: 17160007
- Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin-ethanolamides) in the feline iris. | Woodward, DF., et al. 2007. Br J Pharmacol. 150: 342-52. PMID: 17179945
- Biasing the prostaglandin F2α receptor responses toward EGFR-dependent transactivation of MAPK. | Goupil, E., et al. 2012. Mol Endocrinol. 26: 1189-202. PMID: 22638073
- Prostaglandin FP receptor inhibitor reduces ischemic brain damage and neurotoxicity. | Kim, YT., et al. 2012. Neurobiol Dis. 48: 58-65. PMID: 22709986
- Prostaglandin ethanolamides attenuate damage in a human explant colitis model. | Nicotra, LL., et al. 2013. Prostaglandins Other Lipid Mediat. 100-101: 22-9. PMID: 23380599
- Prostaglandin F2α FP receptor antagonist improves outcomes after experimental traumatic brain injury. | Glushakov, AV., et al. 2013. J Neuroinflammation. 10: 132. PMID: 24172576
- COX-2 mediated induction of endothelium-independent contraction to bradykinin in endotoxin-treated porcine coronary artery. | More, AS., et al. 2014. J Cardiovasc Pharmacol. 64: 209-17. PMID: 25192543
- Prostaglandin F₂α modulates atrial chronotropic hyporesponsiveness to cholinergic stimulation in endotoxemic rats. | Nikoui, V., et al. 2015. Eur J Pharmacol. 748: 149-56. PMID: 25446912
- Reproductive performance of lactating dairy cattle after intrauterine administration of a prostaglandin F2α receptor antagonist 4 days after insemination. | Deaver, SE., et al. 2015. Theriogenology. 83: 560-6. PMID: 25488790
- Prostaglandin FP receptor antagonists: discovery, pharmacological characterization and therapeutic utility. | Sharif, NA. and Klimko, PG. 2019. Br J Pharmacol. 176: 1059-1078. PMID: 29679483
- Stanniocalcin-1 (STC-1), a downstream effector molecule in latanoprost signaling, acts independent of the FP receptor for intraocular pressure reduction. | Roddy, GW., et al. 2020. PLoS One. 15: e0232591. PMID: 32365129
- Effects of NP-1815-PX, a P2X4 Receptor Antagonist, on Contractions in Guinea Pig Tracheal and Bronchial Smooth Muscles. | Obara, K., et al. 2022. Biol Pharm Bull. 45: 1158-1165. PMID: 35908896
Activator of:
PGF2alphaR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AL 8810, 1 mg | sc-205204 | 1 mg | $132.00 | |||
AL 8810, 5 mg | sc-205204A | 5 mg | $493.00 |