Molecular structure of AL 6598, CAS Number: 170291-06-2
AL 6598 (CAS 170291-06-2)
Application:
AL 6598 is isopropyl ester prodrug of AL 6556
CAS Number:
170291-06-2
Molecular Weight:
431.0
Molecular Formula:
C23H39ClO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins such as PGF2α and PGD2, have been shown to reduce IOP. AL 6598 is the isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist that binds to DP receptors with a Ki value of 3.2 µM and demonstrates an EC50 value of 0.80 µM in an in vitro functional assay. Designed to enhance corneal absorption, AL 6598 produces a maximum 53% drop in IOP of the ocular hypertensive monkey with a 1 µg dose given twice daily.
AL 6598 (CAS 170291-06-2) References
- 3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents. | Hellberg, MR., et al. 2002. Bioorg Med Chem. 10: 2031-49. PMID: 11937363
- Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor. | Sharif, NA., et al. 2002. J Ocul Pharmacol Ther. 18: 313-24. PMID: 12222762
- Effects of travoprost on aqueous humor dynamics in monkeys. | Toris, CB., et al. 2005. J Glaucoma. 14: 70-3. PMID: 15650608
- Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes. | Sharif, NA., et al. 2004. J Ocul Pharmacol Ther. 20: 489-508. PMID: 15684809
- Ocular hypotensive DP-class prostaglandin receptor affinities determined by quantitative autoradiography on human eye sections. | Sharif, NA., et al. 2005. J Ocul Pharmacol Ther. 21: 121-32. PMID: 15857278
- Effects of a prostaglandin DP receptor agonist, AL-6598, on aqueous humor dynamics in a nonhuman primate model of glaucoma. | Toris, CB., et al. 2006. J Ocul Pharmacol Ther. 22: 86-92. PMID: 16722794
- Recent developments in the synthesis of prostaglandins and analogues. | Das, S., et al. 2007. Chem Rev. 107: 3286-337. PMID: 17590055
- Cat iris sphincter smooth-muscle contraction: comparison of FP-class prostaglandin analog agonist activities. | Sharif, NA., et al. 2008. J Ocul Pharmacol Ther. 24: 152-63. PMID: 18355130
- ETB2 receptor subtype stimulation relaxes the iris sphincter muscle. | Rocha-Sousa, A., et al. 2009. Physiol Res. 58: 835-842. PMID: 19093744
- Steroid-Induced Ocular Hypertension in Mice Is Differentially Reduced by Selective EP2, EP3, EP4, and IP Prostanoid Receptor Agonists. | Sharif, NA., et al. 2024. Int J Mol Sci. 25: PMID: 38542305
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AL 6598, 500 µg | sc-358796 | 500 µg | $255.00 | |||
AL 6598, 1 mg | sc-358796A | 1 mg | $487.00 |