Molecular structure of Akt Inhibitor XII, Isozyme-Selective, Akti-2
Akt Inhibitor XII, Isozyme-Selective, Akti-2
Application:
Akt Inhibitor XII, Isozyme-Selective, Akti-2 is a cell-permeable Akt1/2 inhibitor with improved solubility and Ak2 selectivity
Purity:
≥97%
Molecular Weight:
747.17
Molecular Formula:
C39H39N7O2•3HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A cell-permeable Akti-1/2- (Cat. No. 124018) derived allosteric inhibitor pair (1:1 regioisomeric mixture) with much improved aqueous solubility (10 mg/ml in a pH 7.4 saline) and Akt2 selectivity (IC50 = 805 nM for Akt2, >10 µM for Akt1/3, and >50 µM for PKA/PKC/SGK). The inhibition is PH domain-dependent and non-competitive with ATP.
Akt Inhibitor XII, Isozyme-Selective, Akti-2 References
- Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity. | Zhao, Z., et al. 2008. Bioorg Med Chem Lett. 18: 49-53. PMID: 18054229
- Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells. | Bokobza, SM., et al. 2014. Oncotarget. 5: 4765-78. PMID: 24946858
- Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer. | Chen, B., et al. 2015. J Exp Clin Cancer Res. 34: 126. PMID: 26490682
Inhibitor of:
Akt2, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Akt Inhibitor XII, Isozyme-Selective, Akti-2, 2 mg | sc-221230 | 2 mg | $480.00 |