Molecular structure of Akt Inhibitor XI, CAS Number: 902779-59-3
Akt Inhibitor XI (CAS 902779-59-3)
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Alternate Names:
FPA 124; 3-Formylchromone thiosemicarbazone, Cu(II)Cl2 Complex
Application:
Akt Inhibitor XI is A cell-permeable copper complex that inhibits Akt kinase activity
CAS Number:
902779-59-3
Molecular Weight:
381.7
Molecular Formula:
C11H9Cl2CuN3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Akt Inhibitor XI is a research tool used to study the role of the protein kinase B (Akt) pathway in cellular processes. It is a compound that selectively inhibits Akt activity, which is central to signaling pathways involved in cell survival, proliferation, and metabolism. By inhibiting Akt, this inhibitor assists in delineating the complex network of intracellular signals that promote cell growth and prevent apoptosis in various cell types. Akt Inhibitor XI is particularly useful for understanding the molecular mechanisms underlying cancer cell survival and for identifying the potential of Akt as a target in cancer research. In addition, it aids in the investigation of Akt′s role in glucose homeostasis and insulin signaling, which is pivotal for research into metabolic disorders.
Akt Inhibitor XI (CAS 902779-59-3) References
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- Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. | Barve, V., et al. 2006. J Med Chem. 49: 3800-8. PMID: 16789737
- Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells. | Brito, PM., et al. 2009. Atherosclerosis. 205: 126-34. PMID: 19108833
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- An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts. | Rybchyn, MS., et al. 2011. J Biol Chem. 286: 23771-9. PMID: 21566129
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- Deregulation of PI3K/Akt/mTOR signaling pathways by isoflavones and its implication in cancer treatment. | Ahmad, A., et al. 2013. Anticancer Agents Med Chem. 13: 1014-24. PMID: 23272911
- The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors. | Chang, WW., et al. 2013. Breast Cancer Res. 15: R39. PMID: 23663564
- Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition. | Tomilov, A., et al. 2018. Pharmacol Res. 137: 89-103. PMID: 30290222
- Calcium Mobilization and Inhibition of Akt Reduced the Binding of PEO-1 Cells to Fibronectin. | Sari Kiliçaslan, SM., et al. 2018. Turk J Pharm Sci. 15: 50-56. PMID: 32454640
- Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase. | Zeng, J., et al. 2021. Biochem J. 478: 2405-2423. PMID: 34198322
- Effects of integrin-linked kinase on protein kinase b, glycogen synthase kinase-3β, and β-catenin molecules in ovarian cancer cells. | Sarı Kılıçaslan, SM. and İncesu, Z. 2021. Iran J Basic Med Sci. 24: 1500-1508. PMID: 35317111
- Interventions on soy isoflavone molecules to improve their therapeutic potential for prostate cancer treatment. | Ajdžanovic, V., et al. 2022. EXCLI J. 21: 941-947. PMID: 36172070
Inhibitor of:
Akt, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Akt Inhibitor XI, 5 mg | sc-221229 | 5 mg | $136.00 |