Molecular structure of Akt Inhibitor X, CAS Number: 925681-41-0
Akt Inhibitor X (CAS 925681-41-0)
See product citations (23)
Alternate Names:
10-(4′-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl; 10-DEBC hydrochloride
Application:
Akt Inhibitor X is a cell permeable, reversible, and selective Akt phosphorylation inhibitor
CAS Number:
925681-41-0
Purity:
>95%
Molecular Weight:
381.34
Molecular Formula:
C20H25ClN2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Akt Inhibitor X is a cell permeable, reversible, and selective inhibitory phenoxazine that suppresses the kinase reactivity of Akt by inhibiting its phosphorylation. In addition, studies show that Akt Inhibitor X deters IGF-I-stimulated nuclear translocation of Akt in Rh1 cells and also suppresses the growth of Rh1, Rh18, and Rh30 cells. Akt is a vital component of the cell survival pathway, functioning in the resistance to apoptosis and improving communication between cells that are damaged. Inhibition of Akt by Akt Inhibitor X via inhibiting phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein, results in greater apoptosis and a decrease in cell signaling. Furthermore, minimal inhibitory effects are seen on pyruvate dehydrogenase kinase isozyme 1 (PDK1), phosphoinositide 3-kinase (PI 3-K), and SGK1.
Akt Inhibitor X (CAS 925681-41-0) References
- p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. | Harada, H., et al. 2001. Proc Natl Acad Sci U S A. 98: 9666-70. PMID: 11493700
- Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells. | Jeong, SJ., et al. 2005. Oncogene. 24: 6719-28. PMID: 16007163
- Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. | Thimmaiah, KN., et al. 2005. J Biol Chem. 280: 31924-35. PMID: 16009706
- Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. | Vucicevic, L., et al. 2011. Autophagy. 7: 40-50. PMID: 20980833
- Inhibition of AMPK-dependent autophagy enhances in vitro antiglioma effect of simvastatin. | Misirkic, M., et al. 2012. Pharmacol Res. 65: 111-9. PMID: 21871960
- Coordinated time-dependent modulation of AMPK/Akt/mTOR signaling and autophagy controls osteogenic differentiation of human mesenchymal stem cells. | Pantovic, A., et al. 2013. Bone. 52: 524-31. PMID: 23111315
- Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling. | Sokołowska, P., et al. 2014. J Mol Neurosci. 52: 48-55. PMID: 24243084
- mTOR is involved in 17β-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1. | Yang, WR., et al. 2015. Mol Reprod Dev. 82: 305-14. PMID: 25739982
- Danggui-Jakyak-San enhances hippocampal long-term potentiation through the ERK/CREB/BDNF cascade. | Yi, JH., et al. 2015. J Ethnopharmacol. 175: 481-9. PMID: 26453932
- Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells. | Hosokawa, Y., et al. 2017. Inflammation. 40: 360-365. PMID: 27896541
- Honokiol and Magnolol Inhibit CXCL10 and CXCL11 Production in IL-27-Stimulated Human Oral Epithelial Cells. | Hosokawa, Y., et al. 2018. Inflammation. 41: 2110-2115. PMID: 30039429
- Carnosic Acid Inhibits CXCR3 Ligands Production in IL-27-Stimulated Human Oral Epithelial Cells. | Hosokawa, I., et al. 2019. Inflammation. 42: 1311-1316. PMID: 30820808
- Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT. | Lin, S., et al. 2020. Diabetes Metab J. 44: 158-172. PMID: 31701691
- 10-DEBC Hydrochloride as a Promising New Agent against Infection of Mycobacterium abscessus. | Lee, DG., et al. 2022. Int J Mol Sci. 23: PMID: 35054777
- Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt. | Janjetovic, K., et al. 2011. Eur J Pharmacol. 651: 41-50. PMID: 21114978
Inhibitor of:
Akt, PARL, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Akt Inhibitor X, 1 mg | sc-203811A | 1 mg | $203.00 | |||
Akt Inhibitor X, 5 mg | sc-203811 | 5 mg | $240.00 | |||
Akt Inhibitor X, 10 mg | sc-203811B | 10 mg | $453.00 | |||
Akt Inhibitor X, 25 mg | sc-203811C | 25 mg | $941.00 | |||
Akt Inhibitor X, 50 mg | sc-203811D | 50 mg | $1569.00 | |||
Akt Inhibitor X, 100 mg | sc-203811E | 100 mg | $2814.00 |