AKAP 79 Antibody (22): sc-135826
- AKAP 79 Antibody (22) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 180-427 of AKAP 79 of human origin
- recommended for detection of AKAP 79 of human origin by WB, IP and IF; not recommended for IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for AKAP 79 Antibody (22). This work is in progress.
AKAP 79 Antibody (22) is a mouse monoclonal IgG1 antibody that detects AKAP 79 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). AKAP 79 plays a crucial role in the spatial and temporal regulation of protein kinase A (PKA) signaling by anchoring PKA to specific subcellular locations, particularly at the postsynaptic densities of excitatory synapses. This localization is vital for the precise modulation of synaptic strength and plasticity, which are essential processes for learning and memory. The interaction of AKAP 79 with PKA ensures that PKA is activated only in the appropriate cellular context, thereby preventing aberrant signaling that could lead to pathological conditions. Additionally, AKAP 79 interacts with other proteins, including the NMDA receptor, further emphasizing AKAP 79′s importance in synaptic signaling pathways. Anti-AKAP 79 antibody (22) enables researchers to gain insights into the dynamics of PKA signaling and its implications in various neurological functions and disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
AKAP 79 Antibody (22) References:
- Ca2+/calmodulin disrupts AKAP79/150 interactions with KCNQ (M-Type) K+ channels. | Bal, M., et al. 2010. J Neurosci. 30: 2311-23. PMID: 20147557
- Ca2+/calmodulin-dependent protein kinase II inhibitors disrupt AKAP79-dependent PKC signaling to GluA1 AMPA receptors. | Brooks, IM. and Tavalin, SJ. 2011. J Biol Chem. 286: 6697-706. PMID: 21156788
- Identification of AKAP79 as a protein phosphatase 1 catalytic binding protein. | Le, AV., et al. 2011. Biochemistry. 50: 5279-91. PMID: 21561082
- AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels. | Zhang, J., et al. 2011. J Neurosci. 31: 7199-211. PMID: 21562284
- AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin. | Gorny, X., et al. 2012. J Neurochem. 122: 714-26. PMID: 22693956
- Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. | Nygren, PJ., et al. 2017. Elife. 6: PMID: 28967377
- Targeting FRET-Based Reporters for cAMP and PKA Activity Using AKAP79. | Musheshe, N., et al. 2018. Sensors (Basel). 18: PMID: 29976855
- AKAP79/150 coordinates leptin-induced PKA signaling to regulate KATP channel trafficking in pancreatic β-cells. | Cochrane, VA., et al. 2021. J Biol Chem. 296: 100442. PMID: 33617875
- AKAP79 enables calcineurin to directly suppress protein kinase A activity. | Church, TW., et al. 2021. Elife. 10: PMID: 34612814
- Regulation of the AKAP79-protein kinase C interaction by Ca2+/Calmodulin. | Faux, MC. and Scott, JD. 1997. J Biol Chem. 272: 17038-44. PMID: 9202019
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AKAP 79 Antibody (22) | sc-135826 | 50 µg/0.5 ml | $322.00 |