AK8 Antibody (4B6): sc-134291

AK8 Antibody (4B6) is a mouse monoclonal IgG1 kappa light chain antibody that detects AK8 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-AK8 antibody (4B6) is available as the non-conjugated isotype antibody. AK8 (4B6) antibody recognizes the protein encoded by the C9orf98 gene located on chromosome 9, which plays a crucial role in cellular energy metabolism and is part of the adenylate kinase family, essential for maintaining cellular ATP levels and regulating nucleotide pools. This function influences various cellular processes, including signal transduction and apoptosis, thereby impacting overall cell health and function. The C9orf98 gene consists of 479 amino acids and exists in two alternatively spliced isoforms, highlighting its potential for diverse functional roles within the cell. Chromosome 9, where AK8 is encoded, is significant in human genetics, as it harbors genes associated with critical biological processes, including those involved in gender determination and vascular integrity. The relevance of AK8 in these pathways underscores the importance of AK8 (4B6) monoclonal antibody in research applications aimed at understanding cellular metabolism and its implications in various diseases.

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AK8 Antibody (4B6) References:

1. DNA sequence and analysis of human chromosome 9.  |  Humphray, SJ., et al. 2004. Nature. 429: 369-74. PMID: 15164053
2. BCR-ABL activates STAT3 via JAK and MEK pathways in human cells.  |  Coppo, P., et al. 2006. Br J Haematol. 134: 171-9. PMID: 16846476
3. BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility.  |  Zheng, X., et al. 2006. BMC Cancer. 6: 262. PMID: 17090304
4. Gene expression fingerprinting for human hereditary hemorrhagic telangiectasia.  |  Fernandez-L, A., et al. 2007. Hum Mol Genet. 16: 1515-33. PMID: 17420163
5. Phenotypic and cytogenetic spectrum of 9p trisomy.  |  Temtamy, SA., et al. 2007. Genet Couns. 18: 29-48. PMID: 17515299
6. Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia.  |  Gardiner, J., et al. 2007. Traffic. 8: 1145-9. PMID: 17605759
7. Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease).  |  Cottin, V., et al. 2007. Respiration. 74: 361-78. PMID: 17641482
8. A humanized IKBKAP transgenic mouse models a tissue-specific human splicing defect.  |  Hims, MM., et al. 2007. Genomics. 90: 389-96. PMID: 17644305
9. Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemia.  |  Burmeister, T., et al. 2007. Haematologica. 92: 1699-702. PMID: 18055996

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AK8 Antibody (4B6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-AK8 Antibody (4B6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AK8 Antibody (4B6) Specifications

Alternate Product Name: AK8

Product Clone Name: 4B6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 381-480

Epitope Target: AK8

Epitope Species: human

Product Reactivity/Detection: AK8

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for AK8 Antibody (4B6): N/A