Molecular structure of Ajmaline, CAS Number: 4360-12-7
Ajmaline (CAS 4360-12-7)
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Alternate Names:
Cardiorythmine; Gilurytmal
CAS Number:
4360-12-7
Molecular Weight:
326.43
Molecular Formula:
C20H26N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Ajmaline is a chemical compound that functions as a class Ia antiarrhythmic agent. It works by blocking sodium channels in cardiac cells, leading to a decrease in the rate of depolarization and conduction velocity in the atria, ventricles, and His-Purkinje system. This mechanism of action results in the prolongation of the action potential duration and effective refractory period in cardiac tissues. By inhibiting the fast inward sodium current during phase 0 of the cardiac action potential, ajmaline helps to stabilize the cardiac cell membrane.
Ajmaline (CAS 4360-12-7) References
- Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action. | Kiesecker, C., et al. 2004. Naunyn Schmiedebergs Arch Pharmacol. 370: 423-35. PMID: 15599706
- Ajmaline test in a patient with chronic renal failure. A pharmacokinetic and pharmacodynamic study. | Padrini, R., et al. 1991. Clin Pharmacokinet. 21: 150-4. PMID: 1884568
- Ajmaline attenuates electrocardiogram characteristics of inferolateral early repolarization. | Roten, L., et al. 2012. Heart Rhythm. 9: 232-9. PMID: 21914496
- The clinical impact of ajmaline challenge in elderly patients with suspected atrioventricular conduction disease. | Conte, G., et al. 2014. Int J Cardiol. 172: 423-7. PMID: 24486065
- Rauvolfia serpentina N-methyltransferases involved in ajmaline and Nβ -methylajmaline biosynthesis belong to a gene family derived from γ-tocopherol C-methyltransferase. | Cázares-Flores, P., et al. 2016. Plant J. 87: 335-42. PMID: 27122470
- Ajmaline-Induced Slowing of Conduction in the Right Ventricular Outflow Tract Cannot Account for ST Elevation in Patients With Type I Brugada ECG. | Antzelevitch, C. and Patocskai, B. 2017. Circ Arrhythm Electrophysiol. 10: PMID: 29038108
- Pharmacokinetics and dromotropic activity of ajmaline in rats with hyperthyroidism. | Hashimoto, Y., et al. 1989. Br J Pharmacol. 96: 163-9. PMID: 2924068
- Ajmaline-induced Epsilon wave: Its role is not only for diagnosis but also for risk stratification. | Ozeke, O., et al. 2018. Int J Cardiol. 264: 99. PMID: 29776580
- Ajmaline-induced Epsilon wave: as a potential interim risk factor between the spontaneous and drug-induced type 1 Brugada electrogram?- Authors' reply. | Takagi, M., et al. 2018. Europace. 20: 1226. PMID: 29893820
- Ajmaline infusion during automated screening in Brugada syndrome and spontaneous Type 1 electrocardiogram unmasks non-suitability for subcutaneous implantable cardioverter-defibrillator. | Özkartal, T., et al. 2019. Eur Heart J. 40: 1888-1889. PMID: 30793741
- Kinetics of ajmaline disposition and pharmacologic response in beagle dogs. | Yasuhara, M., et al. 1987. J Pharmacokinet Biopharm. 15: 39-55. PMID: 3625478
- Prolonged cholestasis after ajmaline-induced acute hepatitis. | Larrey, D., et al. 1986. J Hepatol. 2: 81-7. PMID: 3950363
- Pharmacokinetics and electrophysiological effects of intravenous ajmaline. | Padrini, R., et al. 1993. Clin Pharmacokinet. 25: 408-14. PMID: 8287634
- Cardiovascular effects of ajmaline. | Obayashi, K., et al. 1976. Am Heart J. 92: 487-96. PMID: 961588
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ajmaline, 10 mg | sc-471262A | 10 mg | $118.00 | |||
Ajmaline, 100 mg | sc-471262 | 100 mg | $367.00 |