Ah Receptor Antibody (B-11): sc-74571

Ah Receptor Antibody (B-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects Ah Receptor from mouse, rat, and human origin through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Ah Receptor antibody (B-11) comes in non-conjugated form and various conjugates, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® options. Ah Receptor, also known as aryl hydrocarbon receptor, functions as a ligand-dependent transcription factor mediating biological responses to environmental toxins, particularly 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Upon ligand binding, Ah Receptor forms a complex with Ah Receptor nuclear translocator (Arnt), enabling translocation from cytoplasm to nucleus. This complex binds to specific DNA sequences called xenobiotic responsive elements (XREs), regulating genes involved in detoxification and metabolic processes. Ah Receptor′s ability to interact with various ligands and modulate gene expression plays a vital role in cellular responses to environmental stressors, making Ah Receptor a key target in toxicology and pharmacology research.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Ah Receptor Antibody (B-11) References:

1. Molecular biology of the Ah receptor and its role in carcinogenesis.  |  Safe, S. 2001. Toxicol Lett. 120: 1-7. PMID: 11323156
2. The mechanism of AH receptor protein down-regulation (degradation) and its impact on AH receptor-mediated gene regulation.  |  Pollenz, RS. 2002. Chem Biol Interact. 141: 41-61. PMID: 12213384
3. Ah receptor- and TCDD-mediated liver tumor promotion: clonal selection and expansion of cells evading growth arrest and apoptosis.  |  Bock, KW. and Köhle, C. 2005. Biochem Pharmacol. 69: 1403-8. PMID: 15857604
4. Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor.  |  Köhle, C. and Bock, KW. 2009. Biochem Pharmacol. 77: 689-99. PMID: 18606396
5. Contributions of the Ah receptor to bilirubin homeostasis and its antioxidative and atheroprotective functions.  |  Bock, KW. and Köhle, C. 2010. Biol Chem. 391: 645-53. PMID: 20370320
6. Divergent Ah Receptor Ligand Selectivity during Hominin Evolution.  |  Hubbard, TD., et al. 2016. Mol Biol Evol. 33: 2648-58. PMID: 27486223
7. Enhanced sensitivity of an Ah-receptor system in yeast through condition modification and use of mammalian modifiers.  |  Vazquez-Rivera, E., et al. 2022. Toxicol Rep. 9: 513-520. PMID: 35356645
8. Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback.  |  Dong, F., et al. 2023. Int J Tryptophan Res. 16: 11786469231182508. PMID: 37434789
9. Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation.  |  Morgan, EW., et al. 2023. Int J Tryptophan Res. 16: 11786469231182510. PMID: 37441265
10. Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction.  |  Nebert, DW., et al. 1993. Ann N Y Acad Sci. 685: 624-40. PMID: 8395783

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ah Receptor Antibody (B-11) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-Ah Receptor Antibody (B-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ah Receptor Antibody (B-11) Specifications

Alternate Product Name: aryl hydrocarbon receptor

Product Clone Name: B-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 637-848

Epitope Target: Ah Receptor

Epitope Species: human

Product Reactivity/Detection: Ah Receptor

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for Ah Receptor Antibody (B-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred Ah Receptor antibody is Ah Receptor Antibody (A-3): sc-133088.