Molecular structure of AH-6809, CAS Number: 33458-93-4
AH-6809 (CAS 33458-93-4)
See product citations (2)
Alternate Names:
6-Isopropoxy-9-oxoxanthene-2-carboxylic acid
Application:
AH-6809 is a prostaglandin E2 receptor antagonist
CAS Number:
33458-93-4
Purity:
≥98%
Molecular Weight:
298.29
Molecular Formula:
C17H14O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AH-6809 is a prostaglandin E2 receptor antagonist. The compound has been reported to antagonize the anti-aggregatory activity of BW245C, 9 alpha, 11 beta-PGF2, and PGD2. Mouse prostanoid receptor studies reveal that AH-6809 antagonizes the EP1 and EP2 receptors, and does not bind to the EP4 receptor. AH-6809 may act to also act on DP1. Both EP1 and DP1 receptors induce and elevate intracellular calcium levels, and have the potential to influence the chloride secretory response. Additionally, studies indicate that AH-6809 is a PGE2 antagonist and that it has a more potent inhibitor than Butaprost (sc-221387), and has been used to study the PAR2 receptor. AH-6809 is an inhibitor of DP2 and EP3.
AH-6809 (CAS 33458-93-4) References
- Insulin induces airway smooth muscle contraction. | Schaafsma, D., et al. 2007. Br J Pharmacol. 150: 136-42. PMID: 17160007
- Prostaglandin E2 derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2. | van der Merwe, JQ., et al. 2009. J Pharmacol Exp Ther. 329: 747-52. PMID: 19190238
- PGE2 promotes Ca2+-mediated epithelial barrier disruption through EP1 and EP4 receptors in Caco-2 cell monolayers. | Rodríguez-Lagunas, MJ., et al. 2010. Am J Physiol Cell Physiol. 299: C324-34. PMID: 20484658
- Tumor-secreted PGE2 inhibits CCL5 production in activated macrophages through cAMP/PKA signaling pathway. | Qian, X., et al. 2011. J Biol Chem. 286: 2111-20. PMID: 21097507
- Prostaglandin E(2) in tick saliva regulates macrophage cell migration and cytokine profile. | Poole, NM., et al. 2013. Parasit Vectors. 6: 261. PMID: 24025197
- AH6809, a prostaglandin DP-receptor blocking drug on human platelets. | Keery, RJ. and Lumley, P. 1988. Br J Pharmacol. 94: 745-54. PMID: 2460179
- Evidence that brain prostaglandin E2 is involved in physiological sleep-wake regulation in rats. | Matsumura, H., et al. 1989. Proc Natl Acad Sci U S A. 86: 5666-9. PMID: 2748610
- Ceramide enhances COX-2 expression and VSMC contractile hyperreactivity via ER stress signal activation. | Zhang, H., et al. 2017. Vascul Pharmacol. 96-98: 26-32. PMID: 28797762
- Cellular mechanism underlying oxytocin-stimulated Cl- secretion in rat cauda epididymal epithelium. | Gao, DD., et al. 2020. Am J Physiol Cell Physiol. 319: C630-C640. PMID: 32726160
- Prostaglandin E2 promotes Staphylococcus aureus infection via EP4 receptor in bovine endometrium. | Liu, K., et al. 2021. Microb Pathog. 158: 105019. PMID: 34107344
- 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist. | Woodward, DF., et al. 1995. Biochem Pharmacol. 50: 1731-3. PMID: 7503778
- Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. | Funk, CD., et al. 1993. J Biol Chem. 268: 26767-72. PMID: 8253813
- Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. | Kiriyama, M., et al. 1997. Br J Pharmacol. 122: 217-24. PMID: 9313928
Inhibitor of:
DP, DP2, EP1, EP2, and EP3.Activator of:
EP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AH-6809, 5 mg | sc-201342 | 5 mg | $70.00 | |||
AH-6809, 25 mg | sc-201342A | 25 mg | $282.00 |