AGTPBP1 Antibody (LM-1A7): sc-134251

AGTPBP1 Antibody (LM-1A7) is a mouse monoclonal IgG1 kappa light chain antibody that detects AGTPBP1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-AGTPBP1 antibody (LM-1A7) is available as a non-conjugated monoclonal isotype antibody. AGTPBP1, also known as ATP/GTP-binding protein 1, CCP1 (Cytosolic carboxypeptidase 1), KIAA1035, or NNA1, is a 1,226 amino acid protein that plays a critical role in neuronal survival and function. AGTPBP1 is primarily located in the cytoplasm and is expressed at high levels in the testis, heart, and dorsal root ganglia, with lower expression in skeletal muscle and kidney. AGTPBP1′s presence in these tissues is vital, as AGTPBP1 is implicated in the maintenance of Purkinje cells; loss of AGTPBP1 can lead to degeneration of these neurons, which is associated with significant neurological consequences. AGTPBP1 features an ATP/GTP-binding motif of the P-loop type, a leucine zipper, a nuclear localization signal, a zinc carboxypeptidase signature, and a nucleotide-binding site, all of which are essential for enzymatic activity and interaction with other cellular components. AGTPBP1 exists in two isoforms due to alternative splicing, which may contribute to functional diversity in various cellular contexts.

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AGTPBP1 Antibody (LM-1A7) References:

1. Regenerating motor neurons express Nna1, a novel ATP/GTP-binding protein related to zinc carboxypeptidases.  |  Harris, A., et al. 2000. Mol Cell Neurosci. 16: 578-96. PMID: 11083920
2. Purkinje cell degeneration (pcd) phenotypes caused by mutations in the axotomy-induced gene, Nna1.  |  Fernandez-Gonzalez, A., et al. 2002. Science. 295: 1904-6. PMID: 11884758
3. Dopamine receptor and transporter levels are altered in the brain of Purkinje Cell Degeneration mutant mice.  |  Delis, F., et al. 2004. Neuroscience. 125: 255-68. PMID: 15051164
4. The Purkinje cell degeneration 5J mutation is a single amino acid insertion that destabilizes Nna1 protein.  |  Chakrabarti, L., et al. 2006. Mamm Genome. 17: 103-10. PMID: 16465590
5. Spontaneous and induced mouse mutations with cerebellar dysfunctions: behavior and neurochemistry.  |  Lalonde, R. and Strazielle, C. 2007. Brain Res. 1140: 51-74. PMID: 16499884
6. The carboxypeptidase-like substrate-binding site in Nna1 is essential for the rescue of the Purkinje cell degeneration (pcd) phenotype.  |  Wang, T., et al. 2006. Mol Cell Neurosci. 33: 200-13. PMID: 16952463
7. Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily.  |  Rodriguez de la Vega, M., et al. 2007. FASEB J. 21: 851-65. PMID: 17244817
8. The zinc-binding domain of Nna1 is required to prevent retinal photoreceptor loss and cerebellar ataxia in Purkinje cell degeneration (pcd) mice.  |  Chakrabarti, L., et al. 2008. Vision Res. 48: 1999-2005. PMID: 18602413

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AGTPBP1 Antibody (LM-1A7) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-AGTPBP1 Antibody (LM-1A7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AGTPBP1 Antibody (LM-1A7) Specifications

Alternate Product Name: AGTPBP1

Product Clone Name: LM-1A7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1087-1187

Epitope Target: AGTPBP1

Epitope Species: human

Product Reactivity/Detection: AGTPBP1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for AGTPBP1 Antibody (LM-1A7): N/A