Molecular structure of Agomelatine, CAS Number: 138112-76-2
Agomelatine (CAS 138112-76-2)
See product citations (2)
Alternate Names:
N-(2-(7-Methoxynaphthalen-1-yl)ethyl)acetamide
Application:
Agomelatine is a melatoninergic agonist of the 5-HT2C receptor
CAS Number:
138112-76-2
Purity:
≥98%
Molecular Weight:
243.30
Molecular Formula:
C15H17NO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Agomelatine is a compound that is extensively explored in various research fields due to its interesting chemical profile. In neuroscience research, agomelatine is studied for its influence on circadian rhythm regulation, where it is used to understand the modulation of melatoninergic and serotonergic receptors. This compound is also a focal point in chronobiology studies that investigate the synchronization of biological clocks. Agomelatine is employed to examine its effects on behavior and cognitive function, providing insights into the underlying molecular mechanisms. Furthermore, researchers use agomelatine in the field of biochemistry to study its impact on signaling pathways, which could reveal potential for broader applications in biological systems.
Agomelatine (CAS 138112-76-2) References
- Effect of agomelatine in the chronic mild stress model of depression in the rat. | Papp, M., et al. 2003. Neuropsychopharmacology. 28: 694-703. PMID: 12655314
- The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. | Millan, MJ., et al. 2003. J Pharmacol Exp Ther. 306: 954-64. PMID: 12750432
- Antidepressant action of agomelatine (S 20098) in a transgenic mouse model. | Barden, N., et al. 2005. Prog Neuropsychopharmacol Biol Psychiatry. 29: 908-16. PMID: 16005135
- Mechanisms contributing to the phase-dependent regulation of neurogenesis by the novel antidepressant, agomelatine, in the adult rat hippocampus. | Soumier, A., et al. 2009. Neuropsychopharmacology. 34: 2390-403. PMID: 19571795
- Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice. | Païzanis, E., et al. 2010. Int J Neuropsychopharmacol. 13: 759-74. PMID: 19775499
- Agomelatine, the first melatonergic antidepressant: discovery, characterization and development. | de Bodinat, C., et al. 2010. Nat Rev Drug Discov. 9: 628-42. PMID: 20577266
- Chronic agomelatine treatment corrects behavioral, cellular, and biochemical abnormalities induced by prenatal stress in rats. | Morley-Fletcher, S., et al. 2011. Psychopharmacology (Berl). 217: 301-13. PMID: 21503609
- Electrophysiological effects of repeated administration of agomelatine on the dopamine, norepinephrine, and serotonin systems in the rat brain. | Chenu, F., et al. 2013. Neuropsychopharmacology. 38: 275-84. PMID: 22871919
- Modulation of the inflammatory response in rats chronically treated with the antidepressant agomelatine. | Molteni, R., et al. 2013. Eur Neuropsychopharmacol. 23: 1645-55. PMID: 23622958
- Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures. | Aguiar, CC., et al. 2013. Cell Mol Neurobiol. 33: 825-35. PMID: 23801192
- Agomelatine efficacy and acceptability revisited: systematic review and meta-analysis of published and unpublished randomised trials. | Koesters, M., et al. 2013. Br J Psychiatry. 203: 179-87. PMID: 23999482
- Neuroprotection of agomelatine against cerebral ischemia/reperfusion injury through an antiapoptotic pathway in rat. | Chumboatong, W., et al. 2017. Neurochem Int. 102: 114-122. PMID: 28012846
- Agomelatine-induced modulation of brain-derived neurotrophic factor (BDNF) in the rat hippocampus. | Lu, Y., et al. 2018. Life Sci. 210: 177-184. PMID: 30193943
Inhibitor of:
AANAT, MEL-1B-R, SR-2C, and Thyrotropin-releasing hormone (TRH).Activator of:
Cyclophilin C, MEL-1A-R, MEL-1B-R, and SR-2C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Agomelatine, 10 mg | sc-207266 | 10 mg | $133.00 |