Molecular structure of AGN 192403 hydrochloride, CAS Number: 1021868-90-5
AGN 192403 hydrochloride (CAS 1021868-90-5)
Alternate Names:
(±)-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane hydrochloride
Application:
AGN 192403 hydrochloride is an Ι1 imidazoline binding site selective ligand
CAS Number:
1021868-90-5
Molecular Weight:
189.73
Molecular Formula:
C10H19N•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AGN 192403 hydrochloride is often utilized in biochemical research, particularly for its involvement in studies concerning neurotransmitter systems. It serves as an important tool in neuroscience research to understand the modulation of receptor activities and their impact on neuronal signaling. In addition, AGN 192403 hydrochloride is used to explore the mechanisms underlying synaptic transmission and its potential alterations in various experimental models. This compound is also instrumental in the study of receptor-ligand interactions, providing insights into the molecular dynamics at play within neural communication pathways. Furthermore, AGN 192403 hydrochloride aids in the examination of signal transduction processes, helping researchers to dissect the intricacies of cellular responses triggered by specific receptor activations.
AGN 192403 hydrochloride (CAS 1021868-90-5) References
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- Protective effects of rilmenidine and AGN 192403 on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. | Choi, DH., et al. 2002. Free Radic Biol Med. 33: 1321-33. PMID: 12419464
- Rat clonidine mydriasis model: imidazoline receptors are not involved. | Yu, Y. and Koss, MC. 2005. Auton Neurosci. 117: 17-24. PMID: 15620566
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- Effect of moxonidine on the uveoscleral outflow: role of alpha2-adrenoceptors or i1 imidazoline receptors. | Yang, J., et al. 2009. Curr Eye Res. 34: 287-96. PMID: 19373577
- Pharmacological characterization of the inhibition by moxonidine and agmatine on the cardioaccelerator sympathetic outflow in pithed rats. | Cobos-Puc, LE., et al. 2009. Eur J Pharmacol. 616: 175-82. PMID: 19527708
- Imidazoline versus alpha₂-adrenoceptors in the control of gastric motility in mice. | Zádori, ZS., et al. 2013. Eur J Pharmacol. 705: 61-7. PMID: 23499689
- Evidence for the gastric cytoprotective effect of centrally injected agmatine. | Zádori, ZS., et al. 2014. Brain Res Bull. 108: 51-9. PMID: 25171957
- α2A-adrenoceptors, but not nitric oxide, mediate the peripheral cardiac sympatho-inhibition of moxonidine. | Cobos-Puc, LE., et al. 2016. Eur J Pharmacol. 782: 35-43. PMID: 27112661
- Pharmacological analysis of the cardiac sympatho-inhibitory actions of moxonidine and agmatine in pithed spontaneously hypertensive rats. | Cobos-Puc, LE., et al. 2016. Eur J Pharmacol. 791: 25-36. PMID: 27565220
- Analysing the effect of I1 imidazoline receptor ligands on DSS-induced acute colitis in mice. | Fehér, Á., et al. 2017. Inflammopharmacology. 25: 107-118. PMID: 27873165
- Further analysis of the inhibition by agmatine on the cardiac sympathetic outflow: Role of the α2-adrenoceptor subtypes. | Cobos-Puc, L., et al. 2017. Eur J Pharmacol. 805: 75-83. PMID: 28315344
- Pharmacological analysis of the inhibition produced by moxonidine and agmatine on the vasodepressor sensory CGRPergic outflow in pithed rats. | Rubio-Beltrán, E., et al. 2017. Eur J Pharmacol. 812: 97-103. PMID: 28694067
- Moxonidine inhibits excitatory inputs to airway vagal preganglionic neurons via activation of both α2-adrenoceptors and imidazoline I1 receptors. | Zhou, X., et al. 2020. Brain Res. 1732: 146695. PMID: 32007398
- Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. | Munk, SA., et al. 1996. J Med Chem. 39: 1193-5. PMID: 8632424
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AGN 192403 hydrochloride, 10 mg | sc-203501 | 10 mg | $227.00 | |||
AGN 192403 hydrochloride, 50 mg | sc-203501A | 50 mg | $959.00 |