Aggregation Factor Antibody (B1822): sc-73627
- Aggregation Factor Antibody (B1822) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a 140 kDa polypeptide in the Aggregation Factor of Geodia cydonium origin
- recommended for detection of the 140 kDa polypeptide in the Aggregation Factor of Geodia cydonium origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Aggregation Factor Antibody (B1822). This work is in progress.
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Aggregation Factor Antibody (B1822) is a mouse monoclonal IgG antibody that detects Aggregation Factor in Geodia cydonium by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Aggregation Factor is a crucial protein that plays a significant role in mediating heterophilic interactions and binding of homologous cells, essential for maintaining cellular organization and function within the sponge′s complex tissue architecture. Aggregation Factor has been extensively studied in various sponge species, including Geodia cydonium, Microciona prolifera, and Halichondria bowerbanki, revealing specificity in promoting reduced adhesiveness among different cell types from the same species. Aggregation Factor in Geodia cydonium is characterized as a proteinaceous compound composed of multiple glycoproteins that localize around a unique 90S sunburst-like core structure, vital for function. Aggregation Factor also contains galectin, a critical component required for cell-cell reaggregation, and a 140 kDa polypeptide important for facilitating cell-cell adhesion. The ability of Aggregation Factor to regulate these interactions underscores importance in the biological processes of sponges, making anti-Aggregation Factor antibody (B1822) an invaluable tool for researchers studying cellular dynamics and adhesion mechanisms in marine invertebrates.
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Aggregation Factor Antibody (B1822) References:
- Modulation of myb gene expression in sponges by retinoic acid. | Biesalski, HK., et al. 1992. Oncogene. 7: 1765-74. PMID: 1323819
- Species-specific aggregation factor in sponges. VI. Aggregation receptor from the cell surface. | Müller, WE., et al. 1976. J Cell Sci. 21: 227-41. PMID: 184097
- Intracellular signal transduction pathways in sponges. | Müller, WE., et al. 1990. Electron Microsc Rev. 3: 97-114. PMID: 2103340
- Identification of a cell surface-associated protein involved in mouse neural cell aggregation by means of antibodies against the sponge aggregation factor. | Gramzow, M., et al. 1989. Membr Biochem. 8: 27-38. PMID: 2811703
- Sponge aggregation factor: identification of the specific collagen-binding site by means of a monoclonal antibody. | Gramzow, M., et al. 1988. J Histochem Cytochem. 36: 205-12. PMID: 3335775
- Sponge aggregation factor: in situ localization by fluorescent monoclonal antibody techniques. | Gramzow, M., et al. 1986. J Cell Biochem. 31: 251-8. PMID: 3531218
- Species-specific aggregation factor in sponges. V. Influence on programmed syntheses. | Müller, WE., et al. 1976. Biochim Biophys Acta. 418: 217-25. PMID: 55274
- Species-specific aggregation factor in sponges. XIII. Entire and core structure of the large circular proteid particle from Geodia cydonium. | Müller, WE., et al. 1978. Tissue Cell. 10: 191-9. PMID: 675661
- Fibronectin is apparently not involved in species-specific reaggregation of cells from the marine sponge geodia cydonium. | Conrad, J., et al. 1982. J Cell Biochem. 19: 395-404. PMID: 7161315
- Ubiquitin and ubiquitination in cells from the marine sponge Geodia cydonium. | Müller, WE., et al. 1994. Biol Chem Hoppe Seyler. 375: 53-60. PMID: 8003257
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aggregation Factor Antibody (B1822) | sc-73627 | 100 µg/ml | $322.00 |