Aggregation Factor Antibody (1D2): sc-73520

Aggregation Factor Antibody (1D2) is a mouse monoclonal IgG1 antibody that detects the Aggregation Factor protein of Geodia cydonium origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Aggregation Factor antibody (1D2) is available as the non-conjugated format. Aggregation Factor plays a crucial role in mediating heterophilic interactions and binding between homologous cells, which is essential for maintaining tissue integrity and facilitating cellular communication in sponges. Aggregation Factor has been extensively studied in various sponge species, including Geodia cydonium, Microciona prolifera, and Halichondria bowerbanki, revealing specificity in promoting reduced adhesiveness among different cell types within the same species. Aggregation Factor of Geodia cydonium is a complex proteinaceous compound composed of multiple glycoproteins that surround a unique 90S sunburst-like core structure, which is vital for function. Aggregation Factor contains galectin, a critical component required for cell-cell reaggregation, as well as a 140 kDa polypeptide that is important for facilitating cell-cell adhesion. This intricate structure and composition underscore the importance of Aggregation Factor in cellular interactions and the overall biology of sponges, making anti-Aggregation Factor antibody (1D2) an invaluable tool for researchers studying these processes.

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Aggregation Factor Antibody (1D2) References:

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2. Species-specific association of the cell-aggregation molecule mediates recognition in marine sponges.  |  Jarchow, J. and Burger, MM. 1998. Cell Adhes Commun. 6: 405-14. PMID: 10223356
3. Adhesion of a viral envelope protein to a non-self-binding domain of the aggregation factor in the marine sponge Microciona prolifera.  |  MacKenzie, R., et al. 2000. Biol Bull. 199: 209-11. PMID: 11081741
4. Cloning and expression of the putative aggregation factor from the marine sponge Geodia cydonium.  |  Schütze, J., et al. 2001. J Cell Sci. 114: 3189-98. PMID: 11590245
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6. Adhesion forces in the self-recognition of oligosaccharide epitopes of the proteoglycan aggregation factor of the marine sponge Microciona prolifera.  |  Carvalho de Souza, A., et al. 2009. Glycoconj J. 26: 457-65. PMID: 18843533
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8. Sponge aggregation factor: identification of the specific collagen-binding site by means of a monoclonal antibody.  |  Gramzow, M., et al. 1988. J Histochem Cytochem. 36: 205-12. PMID: 3335775
9. Identification and isolation of the primary aggregation factor from the cell membrane of the sponge Geodia cydonium.  |  Müller, WE., et al. 1985. Mol Cell Biochem. 67: 55-64. PMID: 4022006
10. Aggregation of sponge cells: immunological characterization of the species-specific Geodia aggregation factor.  |  Conrad, J., et al. 1981. J Supramol Struct Cell Biochem. 17: 1-9. PMID: 6798219
11. A galectin links the aggregation factor to cells in the sponge (Geodia cydonium) system.  |  Wagner-Hülsmann, C., et al. 1996. Glycobiology. 6: 785-93. PMID: 9023539