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Agaric acid (CAS 666-99-9)

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Alternate Names:
2-Hydroxy-1,2,3-nonadecanetricarboxylic acid; Agaricic acid; Agaricin
CAS Number:
666-99-9
Molecular Weight:
416.55
Molecular Formula:
C22H40O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Agaric acid sesquihydrate is an organic compound that originates from various mushroom species, including those in the Agaricus genus, from where it gets its name. The term "sesquihydrate" in the name suggests that for every molecule of agaric acid, there are one and a half (or 1.5) molecules of water. This is a less common level of hydration but is seen in some chemical compounds. The water molecules are typically incorporated into the crystal structure of the compound, and this level of hydration can influence the compound′s physical properties, such as its solubility and melting point. Agaric acid itself is a fatty acid, a type of organic compound that has a carboxyl group (-COOH) at one end and a long hydrocarbon chain at the other end. Fatty acids are key components of many biological structures and systems. In its physical form, agaric acid sesquihydrate is typically a white or off-white crystalline powder. It is primarily used in research applications, particularly in studies related to organic and natural products chemistry. It′s also utilized in the study of fungi and their bioactive compounds since fungi produce a wide variety of metabolites with diverse chemical structures.


Agaric acid (CAS 666-99-9) References

  1. Development and characterization of an immobilized enzyme reactor based on glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies.  |  Bartolini, M., et al. 2003. J Chromatogr A. 987: 331-40. PMID: 12613827
  2. A new inhibitor of adenine nucleotide translocase in mitochondria: agaric acid.  |  Chávez, E. and Klapp, M. 1975. Biochem Biophys Res Commun. 67: 272-8. PMID: 128359
  3. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Its dependence on membrane fluidity.  |  García, N., et al. 2005. Mitochondrion. 5: 272-81. PMID: 16050990
  4. The effect of N-ethylmaleimide on permeability transition as induced by carboxyatractyloside, agaric acid, and oleate.  |  García, N., et al. 2008. Cell Biochem Biophys. 51: 81-7. PMID: 18649145
  5. Glucocorticoid induction of fatty-acid synthase mediates the stimulatory effect of the hormone on choline-phosphate cytidylyltransferase activity in fetal rat lung.  |  Xu, ZX., et al. 1990. Biochim Biophys Acta. 1044: 70-6. PMID: 2160286
  6. Metabolic interconnection between the human malarial parasite Plasmodium falciparum and its host erythrocyte. Regulation of ATP levels by means of an adenylate translocator and adenylate kinase.  |  Kanaani, J. and Ginsburg, H. 1989. J Biol Chem. 264: 3194-9. PMID: 2536737
  7. Regulation of fetal lung disaturated phosphatidylcholine synthesis by de novo palmitate supply.  |  Patterson, CE., et al. 1988. Biochim Biophys Acta. 958: 60-9. PMID: 3334868
  8. Agaric acid reduces Salmonella biofilm formation by inhibiting flagellar motility.  |  Lories, B., et al. 2020. Biofilm. 2: 100022. PMID: 33447808
  9. Interaction of Agaric Acid with the Adenine Nucleotide Translocase Induces Mitochondrial Oxidative Stress.  |  Chávez, E., et al. 2020. Biochem Res Int. 2020: 5253108. PMID: 33489376
  10. Inhibition by potential metabolic inhibitors of in vitro adipose tissue lipogenesis.  |  Hood, RL., et al. 1985. Comp Biochem Physiol B. 81: 667-70. PMID: 4028683
  11. The effect of agaric acid on citrate transport in rat liver mitochondria.  |  Chávez, E., et al. 1978. Life Sci. 23: 1423-9. PMID: 713700
  12. Metabolic pathways involved in lipogenesis from lactate and acetate in bovine adipose tissue: effects of metabolic inhibitors.  |  Prior, RL., et al. 1981. Arch Biochem Biophys. 211: 202-10. PMID: 7305365
  13. On the relationship between the mitochondrial inner membrane anion channel and the adenine nucleotide translocase.  |  Powers, MF., et al. 1994. J Biol Chem. 269: 10614-20. PMID: 7511601
  14. Fatty-acid synthase activity and mRNA level in hypertrophic type II cells from silica-treated rats.  |  Rami, J., et al. 1994. Am J Physiol. 267: L128-36. PMID: 8074235

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Agaric acid, 1 g

sc-210767
1 g
$816.00