AGA Antibody (G-10): sc-365848

AGA Antibody (G-10) is a mouse monoclonal IgG1 antibody that detects aspartylglucosaminidase (AGA) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AGA is a crucial enzyme localized in the lysosome, where AGA plays a vital role in the degradation of glycoproteins by cleaving the GlcNAc-Asn bond that links oligosaccharides to these proteins. This enzymatic activity is essential for maintaining cellular homeostasis and preventing the accumulation of undegraded substrates, which can lead to cellular dysfunction. Notably, defects in the gene encoding AGA result in aspartylglucosaminuria (AGU), a lysosomal storage disorder characterized by severe cognitive impairment and mild connective tissue abnormalities. The gene for AGA is located on human chromosome 4, a region known for its extensive gene deserts, which are areas devoid of protein-coding genes. Anti-AGA antibody (G-10) is an invaluable tool for researchers studying the implications of AGA in various biological processes and diseases, providing insights into its function and the consequences of its dysfunction.

The preferred AGA antibody is AGA Antibody (H-8): sc-514075.