Molecular structure of AG 825, CAS Number: 149092-50-2
AG 825 (CAS 149092-50-2)
Alternate Names:
Tyrphostin C15
Application:
AG 825 is a selective ErbB2 (Neu) inhibitor and apoptosis inducer
CAS Number:
149092-50-2
Purity:
≥97%
Molecular Weight:
397.47
Molecular Formula:
C19H15N3O3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AG 825 is shown to be a potent inhibitor of EGFR (epidermal growth factor receptor) and Neu (HER-2) kinases. Mechanistic studies report that this compound inhibits mitogenic signaling elements downstream to the growth receptor kinase. Studies indicate that inhibition of HER-2 causes imbalance between extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase activation. It has also been observed that treatment of cells with AG 825 results in apoptosis induction and inhibition of colony formation.
AG 825 (CAS 149092-50-2) References
- The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells. | Bowers, G., et al. 2001. Oncogene. 20: 1388-97. PMID: 11313882
- Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-2. | Murillo, H., et al. 2001. Cancer Res. 61: 7408-12. PMID: 11606371
- Down-modulation of erbB2 activity is necessary but not enough in the differentiation of 3T3-L1 preadipocytes. | Pagano, E., et al. 2008. J Cell Biochem. 104: 274-85. PMID: 17990290
- Degradation of HER2 receptor through hypericin-mediated photodynamic therapy. | Koval, J., et al. 2010. Photochem Photobiol. 86: 200-5. PMID: 19912559
- EGF and its related growth factors mediate sodium transport in mpkCCDc14 cells via ErbB2 (neu/HER-2) receptor. | Levchenko, V., et al. 2010. J Cell Physiol. 223: 252-9. PMID: 20049896
- Cross-talk between bradykinin and epidermal growth factor in regulating IL-6 production in human airway smooth muscle cells. | Feng, PH., et al. 2010. Chang Gung Med J. 33: 92-9. PMID: 20184800
- RNA interference-directed silencing of VPAC1 receptor inhibits VIP effects on both EGFR and HER2 transactivation and VEGF secretion in human breast cancer cells. | Valdehita, A., et al. 2012. Mol Cell Endocrinol. 348: 241-6. PMID: 21896307
- Neuregulin1-β decreases interleukin-1β-induced RhoA activation, myosin light chain phosphorylation, and endothelial hyperpermeability. | Wu, L., et al. 2016. J Neurochem. 136: 250-7. PMID: 26438054
- Nucleolin and ErbB2 inhibition reduces tumorigenicity of ErbB2-positive breast cancer. | Wolfson, E., et al. 2018. Cell Death Dis. 9: 47. PMID: 29352243
- Identifying key genes, pathways and screening therapeutic agents for manganese-induced Alzheimer disease using bioinformatics analysis. | Ling, J., et al. 2018. Medicine (Baltimore). 97: e10775. PMID: 29851783
- Stimulation of neuroendocrine differentiation in prostate cancer cells by GHRH and its blockade by GHRH antagonists. | Muñoz-Moreno, L., et al. 2020. Invest New Drugs. 38: 746-754. PMID: 31312936
- Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation. | Rahman, A., et al. 2019. Elife. 8: PMID: 31613219
- Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy. | Xu, M., et al. 2022. Commun Biol. 5: 1251. PMID: 36380187
- Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins. | Gazit, A., et al. 1993. J Med Chem. 36: 3556-64. PMID: 7902440
Inhibitor of:
EGFR, ERBIN, Neu, and SH2-B.Activator of:
ErbB-4, HEPN1, and Neu.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AG 825, 2 mg | sc-202045 | 2 mg | $47.00 | |||
AG 825, 5 mg | sc-202045A | 5 mg | $94.00 | |||
AG 825, 10 mg | sc-202045B | 10 mg | $183.00 | |||
AG 825, 100 mg | sc-202045C | 100 mg | $1769.00 |